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Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)

Authors

  • Ying Gao Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Yuesong Pan Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Shangrong Han Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Weiqi Chen Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Jing Jing Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Chunjuan Wang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Yingying Yang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Tingting Wang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Xia Meng Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Xingquan Zhao Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Liping Liu Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Hao Li Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • S Claiborne Johnston Dean's Office, Dell Medical School, University of Texas at Austin, Austin, Texas, USA PubMed articlesGoogle scholar articles
  • Pierre Amarenco Department of Neurology and Stroke Center, Assistance Publique-Hôpitaux de Paris (APHP), Bichat Hospital, INSERM LVTS-U1148, University of Paris, Paris, France Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Philip M Bath Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK PubMed articlesGoogle scholar articles
  • Yongjun Wang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China National Center for Neurological Diseases, Beijing, China Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yilong Wang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China National Center for Neurological Diseases, Beijing, China Chinese Institute for Brain Research, Beijing, China PubMed articlesGoogle scholar articles
  • For the INSPIRES Investigators
    Google scholar articles
  1. Correspondence to Dr Yilong Wang; yilong528{at}aliyun.com; Dr Yongjun Wang; yongjunwang{at}ncrcnd.org.cn
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Citation

Gao Y, Pan Y, Han S For the INSPIRES Investigators, et al
Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)
Stroke and Vascular Neurology 2023;8:doi: 10.1136/svn-2022-002084

Publication history

  • Received October 13, 2022
  • Accepted January 8, 2023
  • First published January 27, 2023.
Online issue publication 
June 23, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.