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Carotid plaque burden is associated with higher levels of total homocysteine
  1. J David Spence
  1. Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada
  1. Correspondence to Dr J David Spence; dspence{at}robarts.ca

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There are several problems with the report of Li et al.1 They studied sex differences, not gender differences.2 They referred to carotid intima-media thickness (IMT) as atherosclerosis; it is not, and plaque burden is a much stronger predictor of cardiovascular risk than IMT.3 They referred to levels of homocysteine (Hcy), but almost certainly what they measured was total homocysteine (tHcy), which includes …

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