Thrombotic thrombocytopenic purpura (TTP) is a life-threatening systemic illness of abrupt
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor (VWF…

Among 141 consecutive patients with neuropsychiatric abnormalities due to cobalamin
deficiency, we found that 40 (28 percent) had no anemia or macrocytosis. The hematocrit was …

Total homocysteine is defined as the sum of all homocysteine species in plasma/serum,
including free and protein-bound forms. In the present review, we compare and evaluate several …

Key Clinical Points Vitamin B 12 Deficiency Vitamin B 12 deficiency causes reversible
megaloblastic anemia, demyelinating neurologic disease, or both. Autoimmune gastritis (…

To determine whether the increased prevalence of low serum cobalamin concentrations in
elderly people represents true deficiency, serum concentrations of cobalamin and folate and …

purpose: Patients with cobalamin (vitamin B12) deficiency usually lack many of the classic
features of severe megaloblastic anemia; because of the low diagnostic specificity of …

▪ Abstract Pernicious anemia is a common cause of megaloblastic anemia throughout the
world and especially in persons of European or African descent. Dietary deficiency of vitamin …

Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated
the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin …

Elevated plasma homocyst(e)ine levels are an independent risk factor for vascular disease.
In a case-control study, the authors studied the associations of fasting plasma homocyst(e)…

Objective: To measure the prevalence of cobalamin (vitamin B 12 ) deficiency in geriatric
outpatients as documented by both low serum cobalamin levels and elevations of serum …