Analysis of shared heritability in common disorders of the brain
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
The clearance of dead cells by efferocytosis
E Boada-Romero, J Martinez, BL Heckmann… - … Reviews Molecular Cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …
induced in a setting-dependent manner. As billions of cells die during mammalian …
[HTML][HTML] The limitless future of RNA therapeutics
Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
…, V Bessi, G Binetti, A Bizarro, R Blesa, M Boada… - Nature …, 2022 - nature.com
Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
Background: AD is characterized by cerebral deposition of β-amyloid plaques with amyloid β-peptide
(Aβ) 42 as the major peptide constituent, along with neurofibrillary tangles and …
(Aβ) 42 as the major peptide constituent, along with neurofibrillary tangles and …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
The Simons Observatory: science goals and forecasts
…, B Beringue, F Bianchini, S Boada… - … of Cosmology and …, 2019 - iopscience.iop.org
The Simons Observatory (SO) is a new cosmic microwave background experiment being
built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the …
built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the …
A global change‐induced biome shift in the Montseny mountains (NE Spain)
J Penuelas, M Boada - Global change biology, 2003 - Wiley Online Library
Shifts in plant species and biome distribution in response to warming have been described
in past climate changes. However, reported evidence of such shifts under current climate …
in past climate changes. However, reported evidence of such shifts under current climate …
[HTML][HTML] Trial of solanezumab for mild dementia due to Alzheimer's disease
Background Alzheimer’s disease is characterized by amyloid-beta (Aβ) plaques and
neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to …
neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to …