Coffee, CYP1A2 genotype, and risk of myocardial infarction
ContextThe association between coffee intake and risk of myocardial infarction (MI) remains
controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic
cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the
CYP1A2* 1A allele are “rapid” caffeine metabolizers, whereas carriers of the variant
CYP1A2* 1F are “slow” caffeine metabolizers. ObjectiveTo determine whether CYP1A2
genotype modifies the association between coffee consumption and risk of acute nonfatal …
controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic
cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the
CYP1A2* 1A allele are “rapid” caffeine metabolizers, whereas carriers of the variant
CYP1A2* 1F are “slow” caffeine metabolizers. ObjectiveTo determine whether CYP1A2
genotype modifies the association between coffee consumption and risk of acute nonfatal …