Matrix metalloproteinases (MMPs) are increasingly being implicated in the pathogenesis of
several CNS diseases. In multiple sclerosis, MMPs could be responsible for the influx of …

Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with
surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the …

Glutathione transferase activity and total glutathione (GSH) content were measured in
several regions of autopsied brain from patients dying with idiopathic Parkinson's disease …

Human endogenous retroviruses (HERVs) constitute 8% of the human genome and have
been implicated in both health and disease. Increased HERV gene activity occurs in …

Reactive astrogliosis is a characteristic response of astrocytes to inflammation and trauma of
the adult CNS. To assess the hypothesis that cytokines from inflammatory mononuclear cells …

By 24 h after mechanical trauma to the cerebral cortex, astroglial reaction begins and injury
sites are infiltrated by activated mononuclear phagocytes derived from blood-borne …

In multiple sclerosis (MS), the influx of activated T lymphocytes into the brain parenchyma
leads to the subsequent damage of oligodendrocytes, the cells that produce central nervous …

Increasing evidence from preclinical and clinical studies link neuroinflammation to
secondary brain injury after stroke, which includes brain ischemia and intracerebral …

Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by
inflammation, demyelination, and neurodegeneration. Emerging research suggests that …

Prominent responses that follow brain trauma include the activation of microglia, the
recruitment of blood-derived macrophages, and astroglial reactivity. Based on evidence that …