User profiles for "author:Paul M Brennan"

Paul M Brennan

Reader, Honorary Consultant Neurosurgeon
Verified email at ed.ac.uk
Cited by 7138

[HTML][HTML] Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre-and post-2005: a systematic review and meta-analysis

MTC Poon, CLM Sudlow, JD Figueroa, PM Brennan - Scientific reports, 2020 - nature.com
Translation of survival benefits observed in glioblastoma clinical trials to populations and to
longer-term survival remains uncertain. We aimed to assess if≥ 2-year survival has …

[HTML][HTML] Liquid biopsies: the future of cancer early detection

S Connal, JM Cameron, A Sala, PM Brennan… - Journal of translational …, 2023 - Springer
Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale
causing emotional, physical, and financial strains on individuals, families, and health care …

Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection

A Sala, DJ Anderson, PM Brennan, HJ Butler… - Cancer letters, 2020 - Elsevier
Abstract Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by
scientific researchers to improve diagnosis and treatment of cancer, using various biofluids …

Somatic retrotransposition alters the genetic landscape of the human brain

JK Baillie, MW Barnett, KR Upton, DJ Gerhardt… - Nature, 2011 - nature.com
Retrotransposons are mobile genetic elements that use a germline 'copy-and-
paste'mechanism to spread throughout metazoan genomes. At least 50 per cent of the …

[PDF][PDF] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

E Gangoso, B Southgate, L Bradley, S Rus… - Cell, 2021 - cell.com
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

[HTML][HTML] Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

R Shukla, KR Upton, M Muñoz-Lopez, DJ Gerhardt… - Cell, 2013 - cell.com
Summary LINE-1 (L1) retrotransposons are mobile genetic elements comprising∼ 17% of
the human genome. New L1 insertions can profoundly alter gene function and cause …

[PDF][PDF] Ubiquitous L1 mosaicism in hippocampal neurons

KR Upton, DJ Gerhardt, JS Jesuadian, SR Richardson… - Cell, 2015 - cell.com
Summary Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …

Prion protein accumulation and neuroprotection in hypoxic brain damage

NF McLennan, PM Brennan, A McNeill, I Davies… - The American journal of …, 2004 - Elsevier
The function of the normal conformational isoform of prion protein, PrPC, remains unclear
although lines of research have suggested a role in the cellular response to oxidative stress …

Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity

PM Brennan, GD Murray, GM Teasdale - Journal of neurosurgery, 2018 - thejns.org
OBJECTIVE Glasgow Coma Scale (GCS) scores and pupil responses are key indicators of
the severity of traumatic brain damage. The aim of this study was to determine what …

The management and outcome for patients with chronic subdural hematoma: a prospective, multicenter, observational cohort study in the United Kingdom

PM Brennan, AG Kolias, AJ Joannides, J Shapey… - Journal of …, 2016 - thejns.org
OBJECTIVE Symptomatic chronic subdural hematoma (CSDH) will become an increasingly
common presentation in neurosurgical practice as the population ages, but quality evidence …