User profiles for "author:Paul M Brennan"
Paul M BrennanReader, Honorary Consultant Neurosurgeon Verified email at ed.ac.uk Cited by 7138 |
[HTML][HTML] Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre-and post-2005: a systematic review and meta-analysis
Translation of survival benefits observed in glioblastoma clinical trials to populations and to
longer-term survival remains uncertain. We aimed to assess if≥ 2-year survival has …
longer-term survival remains uncertain. We aimed to assess if≥ 2-year survival has …
[HTML][HTML] Liquid biopsies: the future of cancer early detection
S Connal, JM Cameron, A Sala, PM Brennan… - Journal of translational …, 2023 - Springer
Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale
causing emotional, physical, and financial strains on individuals, families, and health care …
causing emotional, physical, and financial strains on individuals, families, and health care …
Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection
A Sala, DJ Anderson, PM Brennan, HJ Butler… - Cancer letters, 2020 - Elsevier
Abstract Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by
scientific researchers to improve diagnosis and treatment of cancer, using various biofluids …
scientific researchers to improve diagnosis and treatment of cancer, using various biofluids …
Somatic retrotransposition alters the genetic landscape of the human brain
Retrotransposons are mobile genetic elements that use a germline 'copy-and-
paste'mechanism to spread throughout metazoan genomes. At least 50 per cent of the …
paste'mechanism to spread throughout metazoan genomes. At least 50 per cent of the …
[PDF][PDF] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
[HTML][HTML] Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma
Summary LINE-1 (L1) retrotransposons are mobile genetic elements comprising∼ 17% of
the human genome. New L1 insertions can profoundly alter gene function and cause …
the human genome. New L1 insertions can profoundly alter gene function and cause …
[PDF][PDF] Ubiquitous L1 mosaicism in hippocampal neurons
Summary Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …
Prion protein accumulation and neuroprotection in hypoxic brain damage
NF McLennan, PM Brennan, A McNeill, I Davies… - The American journal of …, 2004 - Elsevier
The function of the normal conformational isoform of prion protein, PrPC, remains unclear
although lines of research have suggested a role in the cellular response to oxidative stress …
although lines of research have suggested a role in the cellular response to oxidative stress …
Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity
PM Brennan, GD Murray, GM Teasdale - Journal of neurosurgery, 2018 - thejns.org
OBJECTIVE Glasgow Coma Scale (GCS) scores and pupil responses are key indicators of
the severity of traumatic brain damage. The aim of this study was to determine what …
the severity of traumatic brain damage. The aim of this study was to determine what …
The management and outcome for patients with chronic subdural hematoma: a prospective, multicenter, observational cohort study in the United Kingdom
OBJECTIVE Symptomatic chronic subdural hematoma (CSDH) will become an increasingly
common presentation in neurosurgical practice as the population ages, but quality evidence …
common presentation in neurosurgical practice as the population ages, but quality evidence …