Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons.
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …

Importance Whether intravenous thrombolysis is needed in combination with mechanical
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …

The localization of glucocorticoid receptor (GR) immunoreactivity and mRNA in the adult rat
brain was examined by light microscopic and electron microscopic immunohistochemistries …

Background and Purpose—Mechanisms of initiation, progression and rupture of cerebral
aneurysms have not yet been fully understood despite its clinical significance. Matrix …

Oxidized low density lipoprotein (Ox-LDL) induces apoptosis in vascular smooth muscle
cells (VSMCs), which may increase atherosclerotic plaque instability. In this study, we …

Background and Purpose—Rupture of cerebral aneurysm (CA) is the major cause of
subarachnoid hemorrhage. Molecular mechanisms of this disease, however, remain …

OBJECTIVE: Posttreatment sequelae of palliatively treated cerebral arteriovenous
malformations (AVMs) were studied to evaluate the significance of these nonradical …

Infantile spasms (IS) is the most severe and common form of epilepsy occurring in the first
year of life. At least half of IS cases are idiopathic in origin, with others presumed to arise …

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations of the
survival of motor neuron 1 (SMN1) gene. In the pathogenesis of SMA, pathological changes …

Background Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors 150 or more
kinds of proteins to the human cell surface. There are at least 26 genes involved in the …