White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter
hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or …

Background Newtonian fluid model has been commonly applied in simulating cerebral
blood flow in intracranial atherosclerotic stenosis (ICAS) cases using computational fluid …

Objective To investigate whether hemodynamic features of symptomatic intracranial
atherosclerotic stenosis (sICAS) might correlate with the risk of stroke relapse, using a …

Background and Purpose—In patients with symptomatic intracranial atherosclerotic
stenosis, identifying the underlying stroke mechanisms may inform secondary prevention …

Background Intracranial atherosclerotic stenosis is an important etiology subtype of ischemic
stroke. Stenosis severity was thought to be the main reference index for clinical treatment …

Background and Purpose: Understanding the mechanisms underlying progression/
regression of symptomatic intracranial atherosclerotic stenosis (sICAS) will inform secondary …

We aimed to investigate the roles of antegrade residual flow and leptomeningeal collateral
flow in sustaining cerebral perfusion distal to an intracranial atherosclerotic stenosis (ICAS) …

Tight junctions (TJs) are the most important structure of the blood–brain barrier (BBB).
Studies have shown that triggering of white matter lesions (WMLs) may be related to a BBB …

Artery-to-artery embolism (AAE) is a common stroke mechanism in intracranial
atherosclerotic disease (ICAD), associated with a considerable risk of recurrent stroke. We …

Background and purpose Symptomatic intracranial atherosclerotic stenosis (sICAS) is
associated with a considerable risk of recurrent stroke despite contemporarily optimal …