User profiles for "author:Lauren Sanders"

Lauren M Sanders

NASA Ames GeneLab
Verified email at nasa.gov
Cited by 230

Biomonitoring and precision health in deep space supported by artificial intelligence

RT Scott, LM Sanders, EL Antonsen… - Nature Machine …, 2023 - nature.com
Human exploration of deep space will involve missions of substantial distance and duration.
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …

Biological research and self-driving labs in deep space supported by artificial intelligence

LM Sanders, RT Scott, JH Yang, AA Qutub… - Nature Machine …, 2023 - nature.com
Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Gait, gait variability and the risk of multiple incident falls in older people: a population-based study

ML Callisaya, L Blizzard, MD Schmidt, KL Martin… - Age and …, 2011 - academic.oup.com
Background: it is uncertain as to which measures of gait best predict those who are likely to
fall. Our aim was to investigate the associations of gait and gait variability measures with …

Cognitive function, gait, and gait variability in older people: a population-based study

KL Martin, L Blizzard, AG Wood… - … Series A: Biomedical …, 2013 - academic.oup.com
Background. Gait impairments are associated with falls and loss of independence. The study
of factors associated with poorer gait may assist in developing methods to preserve mobility …

Cognitive function modifies the effect of physiological function on the risk of multiple falls—a population-based study

KL Martin, L Blizzard, VK Srikanth… - … Series A: Biomedical …, 2013 - academic.oup.com
Background. There is a poor understanding of the interplay between cognitive and
physiological functions in leading to falls. We hypothesized that poorer physiological …

Long‐term safety and efficacy of Eculizumab in Aquaporin‐4 IgG‐positive NMOSD

DM Wingerchuk, K Fujihara, J Palace… - Annals of …, 2021 - Wiley Online Library
Objective During PREVENT (NCT01892345), eculizumab significantly reduced relapse risk
versus placebo in patients with aquaporin‐4 immunoglobulin G‐positive neuromyelitis …

The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information

JH Morris, K Soman, RE Akbas, X Zhou, B Smith… - …, 2023 - academic.oup.com
Abstract Motivation Knowledge graphs (KGs) are being adopted in industry, commerce and
academia. Biomedical KG presents a challenge due to the complexity, size and …

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

BJ Golbourn, ME Halbert, K Halligan, S Varadharajan… - Nature cancer, 2022 - nature.com
Diffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M)
are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic …

Melbourne mobile stroke unit and reperfusion therapy: greater clinical impact of thrombectomy than thrombolysis

H Zhao, S Coote, D Easton, F Langenberg… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—Mobile stroke units (MSUs) are increasingly used worldwide to
provide prehospital triage and treatment. The benefits of MSUs in giving earlier thrombolysis …

Monash transient ischemic attack triaging treatment: safety of a transient ischemic attack mechanism-based outpatient model of care

LM Sanders, VK Srikanth, DJ Jolley, V Sundararajan… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Controversy surrounds the need for routine hospital admission
for transient ischemic attack. The Monash Transient Ischemic Attack Triaging Treatment …