Ischaemic stroke

BCV Campbell, DA De Silva, MR Macleod… - Nature reviews Disease …, 2019 - nature.com
Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Extending thrombolysis to 4· 5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

BCV Campbell, H Ma, PA Ringleb, MW Parsons… - The Lancet, 2019 - thelancet.com
Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke

BCV Campbell, GA Donnan, KR Lees… - The Lancet …, 2015 - thelancet.com
Background Results of initial randomised trials of endovascular treatment for ischaemic
stroke, published in 2013, were neutral but limited by the selection criteria used, early …

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

M Goyal, BK Menon, WH Van Zwam, DWJ Dippel… - The Lancet, 2016 - thelancet.com
Background In 2015, five randomised trials showed efficacy of endovascular thrombectomy
over standard medical care in patients with acute ischaemic stroke caused by occlusion of …

[HTML][HTML] Endovascular therapy for ischemic stroke with perfusion-imaging selection

BCV Campbell, PJ Mitchell, TJ Kleinig… - … England Journal of …, 2015 - Mass Medical Soc
Background Trials of endovascular therapy for ischemic stroke have produced variable
results. We conducted this study to test whether more advanced imaging selection, recently …

Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke

D Sacks, B Baxter, BCV Campbell… - … journal of stroke, 2018 - journals.sagepub.com
Endovascular therapy (EVT) for acute ischemic stroke in selected patients has recently been
proven effective in several clinical trials, and the widespread adoption of thrombectomy into …

[HTML][HTML] Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke

H Ma, BCV Campbell, MW Parsons… - … England Journal of …, 2019 - Mass Medical Soc
Background The time to initiate intravenous thrombolysis for acute ischemic stroke is
generally limited to within 4.5 hours after the onset of symptoms. Some trials have suggested …

The Heidelberg bleeding classification: classification of bleeding events after ischemic stroke and reperfusion therapy

R von Kummer, JP Broderick, BCV Campbell… - Stroke, 2015 - Am Heart Assoc
2982 Stroke October 2015 threshold between PH1 and PH2 was not clarified. 10
Regardless, in the ECASS, only PH2, but not PH1 or HI, was associated with early …

[HTML][HTML] Tenecteplase versus alteplase before thrombectomy for ischemic stroke

BCV Campbell, PJ Mitchell, L Churilov… - … England Journal of …, 2018 - Mass Medical Soc
Background Intravenous infusion of alteplase is used for thrombolysis before endovascular
thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has …

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

MD Hill, M Goyal, BK Menon, RG Nogueira… - The Lancet, 2020 - thelancet.com
Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia …