User profiles for "author:Audrey C Leasure"

Audrey C. Leasure, MD MHS

Yale New Haven Hospital
Verified email at yale.edu
Cited by 1306

Intracerebral hemorrhage location and functional outcomes of patients: a systematic literature review and meta-analysis

A Sreekrishnan, JL Dearborn, DM Greer, FD Shi… - Neurocritical care, 2016 - Springer
Abstract Background and Purpose Intracerebral hemorrhage (ICH) has the highest mortality
rate among all strokes. While ICH location, lobar versus non-lobar, has been established as …

Association of intensive blood pressure reduction with risk of hematoma expansion in patients with deep intracerebral hemorrhage

AC Leasure, AI Qureshi, SB Murthy, H Kamel… - JAMA …, 2019 - jamanetwork.com
Importance Hypertension is the strongest risk factor for spontaneous intracerebral
hemorrhage (ICH) involving deep brain regions, but it appears to be unknown if intensive …

Racial/ethnic disparities in the risk of intracerebral hemorrhage recurrence

AC Leasure, ZA King, V Torres-Lopez, SB Murthy… - Neurology, 2020 - AAN Enterprises
Objective To estimate the risk of intracerebral hemorrhage (ICH) recurrence in a large,
diverse, US-based population and to identify racial/ethnic and socioeconomic subgroups at …

Association of serum IL-6 (interleukin 6) with functional outcome after intracerebral hemorrhage

AC Leasure, LR Kuohn, KN Vanent, MB Bevers… - Stroke, 2021 - Am Heart Assoc
Background and Objectives: IL-6 (interleukin 6) is a proinflammatory cytokine and an
established biomarker in acute brain injury. We sought to determine whether admission IL-6 …

A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways

Y Ye, RB Noche, N Szejko, CP Both, JN Acosta… - Geroscience, 2023 - Springer
Frailty is an aging-related clinical phenotype defined as a state in which there is an increase
in a person's vulnerability for dependency and/or mortality when exposed to a stressor …

Rate of perihematomal edema expansion predicts outcome after intracerebral hemorrhage

S Urday, LA Beslow, F Dai, F Zhang… - Critical care …, 2016 - journals.lww.com
Objectives: Intracerebral hemorrhage is a devastating disorder with no current treatment.
Whether perihematomal edema is an independent predictor of neurologic outcome is …

Intracerebral hemorrhage in patients with COVID-19: an analysis from the COVID-19 cardiovascular disease registry

AC Leasure, YM Khan, R Iyer, MSV Elkind, LH Sansing… - Stroke, 2021 - Am Heart Assoc
Methods Data are available from the American Heart Association after approval of a
research proposal (www. heart. org/qualityresearch). We performed a retrospective, cross …

Identification and validation of hematoma volume cutoffs in spontaneous, supratentorial deep intracerebral hemorrhage

AC Leasure, KN Sheth, M Comeau, C Aldridge… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—Clinical trials in spontaneous intracerebral hemorrhage (ICH)
have used volume cutoffs as inclusion criteria to select populations in which the effects of …

Intensive blood pressure reduction and perihematomal edema expansion in deep intracerebral hemorrhage

AC Leasure, AI Qureshi, SB Murthy, H Kamel… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—It is unknown whether blood pressure (BP) reduction influences
secondary brain injury in spontaneous intracerebral hemorrhage (ICH). We tested the …

Admission hemoglobin levels are associated with functional outcome in spontaneous intracerebral hemorrhage

JN Acosta, AC Leasure, LR Kuohn, CP Both… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: To test the hypothesis that admission hemoglobin levels are associated with
outcome in primary, nontraumatic intracerebral hemorrhage. DESIGN: Individual patient …