Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies

A Lauer, W Pfeilschifter, CB Schaffer, EH Lo… - The Lancet …, 2013 - thelancet.com
Little is known about the pathophysiology of intracerebral haemorrhage that occurs during
anticoagulant treatment. In observational studies, investigators have reported larger …

Statins in intracerebral hemorrhage

A Lauer, SM Greenberg, ME Gurol - Current atherosclerosis reports, 2015 - Springer
While statins play an indisputable role in primary and secondary prevention of ischemic
cardiovascular and cerebrovascular disease, a concern exists regarding a possible …

Total magnetic resonance imaging burden of small vessel disease in cerebral amyloid angiopathy: an imaging-pathologic study of concept validation

A Charidimou, S Martinez-Ramirez, YD Reijmer… - JAMA …, 2016 - jamanetwork.com
Importance Cerebral amyloid angiopathy (CAA) is characteristically associated with
magnetic resonance imaging (MRI) biomarkers of small vessel brain injury, including strictly …

Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results

LH Schwamm, O Wu, SS Song, LL Latour… - Annals of …, 2018 - Wiley Online Library
Objective Most acute ischemic stroke (AIS) patients with unwitnessed symptom onset are
ineligible for intravenous thrombolysis due to timing alone. Lesion evolution on fluid …

Microbleed and microinfarct detection in amyloid angiopathy: a high-resolution MRI-histopathology study

SJ van Veluw, A Charidimou, AJ van der Kouwe… - Brain, 2016 - academic.oup.com
Cerebral amyloid angiopathy is a common neuropathological finding in the ageing human
brain, associated with cognitive impairment. Neuroimaging markers of severe cerebral …

Clinical imaging factors associated with infarct progression in patients with ischemic stroke during transfer for mechanical thrombectomy

G Boulouis, A Lauer, AK Siddiqui, A Charidimou… - JAMA …, 2017 - jamanetwork.com
Importance When transferred from a referring hospital (RH) to a thrombectomy-capable
stroke center (TCSC), patients with initially favorable imaging profiles (Alberta Stroke …

Delays in the air or ground transfer of patients for endovascular thrombectomy

RW Regenhardt, AP Mecca, SA Flavin, G Boulouis… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—For suspected large vessel occlusion patients efficient transfer to
centers that provide endovascular therapy (ET) is critical to maximizing treatment …

[HTML][HTML] Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy

A Lauer, SL Speroni, M Choi, X Da, C Duncan… - Nature …, 2023 - nature.com
Blood-brain barrier disruption marks the onset of cerebral adrenoleukodystrophy (CALD), a
devastating cerebral demyelinating disease caused by loss of ABCD1 gene function. The …

Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage

A Lauer, FA Cianchetti, EM Van Cott, F Schlunk… - Circulation, 2011 - Am Heart Assoc
Background—The direct thrombin inhibitor dabigatran etexilate (DE) may constitute a future
replacement of vitamin K antagonists for long-term anticoagulation. Whereas warfarin …

Intracerebral Hemorrhage Formation Under Direct Oral Anticoagulants: Clinical and Translational Evidence

C Foerch, EH Lo, K van Leyen, A Lauer, JH Schaefer - Stroke, 2019 - Am Heart Assoc
Methods Clinical and experimental studies were identified by performing a PubMed and
EMBASE database search using the following term:(anticoagulation OR noac OR vka OR …