Abstract
1. In this study, we investigated the effect of a radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), on cerebral damage induced by rat middle cerebral artery (MCA) occlusion, and further measured the hydroxyl radical level at the ischemic border zone using a microdialysis technique. 2. MCI-186, at a dose of 3 mg/kg per 30 min, was administered as a continuous infusion two times for 30 min, starting 20 min and then 80 min after Rose Bengal injection. 3. MCI-186 significantly (P < 0.05) reduced size of cerebral damage 24 hr after MCA occlusion and significantly (P < 0.05) reduced hydroxyl radical level.
MeSH terms
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Animals
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Antipyrine / analogs & derivatives*
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Antipyrine / pharmacology
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Antipyrine / therapeutic use
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Brain / blood supply*
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Brain Ischemia / drug therapy*
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Brain Ischemia / metabolism
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Cerebral Arteries / drug effects*
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Cerebral Arteries / physiology
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Constriction
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Edaravone
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Free Radical Scavengers / pharmacology
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Free Radical Scavengers / therapeutic use*
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Hydroxybenzoates / metabolism
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Hydroxyl Radical / metabolism
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Male
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Rats
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Rats, Wistar
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Visual Cortex / drug effects*
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Visual Cortex / injuries
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Visual Cortex / metabolism
Substances
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Free Radical Scavengers
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Hydroxybenzoates
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Hydroxyl Radical
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2,3-dihydroxybenzoic acid
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Edaravone
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Antipyrine