Intracerebral hemorrhage in a primate model: effect on regional cerebral blood flow

R Bullock; J Brock-Utne; J van Dellen; G Blake

doi:10.1016/0090-3019(88)90065-1

Intracerebral hemorrhage in a primate model: effect on regional cerebral blood flow

Surg Neurol. 1988 Feb;29(2):101-7. doi: 10.1016/0090-3019(88)90065-1.

Authors

R Bullock¹, J Brock-Utne, J van Dellen, G Blake

Affiliation

¹ Department of Neurosurgery, Wentworth Hospital, Durban, South Africa.

PMID: 3336844
DOI: 10.1016/0090-3019(88)90065-1

Abstract

The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 +/- 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / pathology
Cerebral Hemorrhage / pathology
Cerebral Hemorrhage / physiopathology*
Cerebrovascular Circulation*
Chlorocebus aethiops
Hematoma / pathology
Intracranial Pressure
Specific Gravity