Plaque Characteristics of Patients with Symptomatic Mild Carotid Artery Stenosis

J Stroke Cerebrovasc Dis. 2018 Jul;27(7):1930-1936. doi: 10.1016/j.jstrokecerebrovasdis.2018.02.032. Epub 2018 Mar 20.

Abstract

Background: Carotid revascularization may be considered for severe stenosis, but its use for symptomatic mild stenosis (<50%) with vulnerable plaque or ulcer remains uncertain. The characteristics of patients with symptomatic mild stenosis who underwent revascularization are reviewed.

Methods: The subjects of this study were 18 patients with symptomatic mild stenosis (<50%) on angiography from among 175 patients who underwent revascularization in our department. The plaques were evaluated by black-blood magnetic resonance imaging (BB-MRI) and ultrasonography (US) and classified into 2 types: type 1 (n = 15), a lesion with an ulcer or mobile plaque or thrombosis on angiography or US; and type 2 (n = 3), a lesion without any of the above. Fourteen patients underwent carotid endarterectomy (CEA), and 4 patients underwent carotid artery stenting.

Results: The stenosis on angiography was 27.2% ± 10.7 (5%-41%), and the area carotid artery stenosis rate on US was 69.8 ± 14.5% (44.5%-97%). The stenosis rate of these 2 methods was not at all correlated. In type 1 plaque that underwent CEA, 10 of 11 patients had vulnerable plaque by histopathology, and 1 patient had thrombus on the plaque by operative findings. In type 2 plaque that underwent CEA, all patients had vulnerable plaque by histopathology. During the follow-up period, none of the patients had restenosis or stroke.

Conclusions: The findings of US and BB-MRI in patients with symptomatic mild stenosis (<50%) on angiography are important for determining treatment. If BB-MRI or US shows the findings of vulnerable plaque in mild stenosis, surgical treatment may be considered for these patients.

Keywords: Carotid endarterectomy; carotid artery stenting; mild carotid artery stenosis; symptomatic.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carotid Arteries / diagnostic imaging*
  • Carotid Arteries / pathology*
  • Carotid Arteries / surgery
  • Carotid Stenosis / diagnostic imaging*
  • Carotid Stenosis / pathology*
  • Carotid Stenosis / surgery
  • Cerebral Angiography
  • Endarterectomy, Carotid
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Plaque, Atherosclerotic / diagnostic imaging*
  • Plaque, Atherosclerotic / pathology*
  • Plaque, Atherosclerotic / surgery
  • Stents
  • Ultrasonography