Abstract
Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy and an acquired antibody-mediated coagulopathy associated with purpura fulminans and generalized thromboembolism. There are no published reports of cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We report 2 cases that highlight an unusual presentation of VZV infection: CVST with primary varicella infection. One patient had extensive CVST with coexistent middle cerebral artery involvement. Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses.
Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Adolescent
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Anticoagulants / therapeutic use
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Antiviral Agents / therapeutic use
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Cerebral Angiography / methods
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Cerebral Arteries / pathology
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Cerebral Arteries / virology*
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Diffusion Magnetic Resonance Imaging
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Herpes Zoster / complications
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Herpes Zoster / diagnosis
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Herpes Zoster / drug therapy
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Herpes Zoster / virology*
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Herpesvirus 3, Human / isolation & purification*
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Humans
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Infarction, Middle Cerebral Artery / virology
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Magnetic Resonance Angiography
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Male
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Phlebography / methods
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Sinus Thrombosis, Intracranial / diagnosis
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Sinus Thrombosis, Intracranial / drug therapy
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Sinus Thrombosis, Intracranial / virology*
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Treatment Outcome
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Young Adult
Substances
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Anticoagulants
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Antiviral Agents