24p3 and its receptor: dawn of a new iron age?

Des R Richardson

doi:10.1016/j.cell.2005.12.008

24p3 and its receptor: dawn of a new iron age?

Cell. 2005 Dec 29;123(7):1175-7. doi: 10.1016/j.cell.2005.12.008.

Author

Des R Richardson¹

Affiliation

¹ Children's Cancer Institute Australia for Medical Research, Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031, Australia. d.richardson@pathology.usyd.edu.au

PMID: 16377555
DOI: 10.1016/j.cell.2005.12.008

Abstract

24p3 is a secreted protein that induces apoptosis in leukocytes. Recently, 24p3 has been shown to bind to iron-containing bacterial siderophores. In this issue of Cell, a receptor that internalizes 24p3 is identified. Internalization of iron bound to 24p3 prevents apoptosis. In contrast, internalization of the apo form of 24p3 that does not contain iron leads to cellular iron efflux and apoptosis via the proapoptotic protein Bim.

Publication types

Review
Comment

MeSH terms

Acute-Phase Proteins / metabolism*
Animals
Apoptosis
Apoptosis Regulatory Proteins / metabolism
Bcl-2-Like Protein 11
Humans
Iron / metabolism*
Lipocalin-2
Lipocalins
Membrane Proteins / metabolism
Proto-Oncogene Proteins / metabolism*
Receptors, Cell Surface / metabolism
Siderophores / metabolism

Substances

Acute-Phase Proteins
Apoptosis Regulatory Proteins
BCL2L11 protein, human
Bcl-2-Like Protein 11
LCN2 protein, human
Lipocalin-2
Lipocalins
Membrane Proteins
Proto-Oncogene Proteins
Receptors, Cell Surface
Siderophores
Iron