Abstract
Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.
Publication types
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Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Aged
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Blood Coagulation / drug effects
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Blood Coagulation / physiology
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Blood Glucose / physiology
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Brain Ischemia / drug therapy
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Brain Ischemia / mortality*
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Brain Ischemia / physiopathology
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Causality
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Cerebrovascular Disorders / drug therapy
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Cerebrovascular Disorders / mortality*
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Cerebrovascular Disorders / physiopathology
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Comorbidity
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Drug Interactions / physiology
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Female
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Fibrinolytic Agents / pharmacology*
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Fibrinolytic Agents / therapeutic use
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Humans
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Injections, Intravenous
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Male
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Middle Aged
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Nicotiana / metabolism
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Recovery of Function / drug effects
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Recovery of Function / physiology
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Sex Factors
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Smoking / epidemiology*
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Stroke / drug therapy
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Stroke / mortality*
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Stroke / physiopathology
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Survival Rate
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Treatment Outcome
Substances
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Blood Glucose
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Fibrinolytic Agents