Abstract
Combined IV and intra-arterial (IA) thrombolysis for acute ischemic stroke may offer advantages over either technique alone. Sixty-two nonrandomized patients with NIH Stroke Scale scores of > or =10 who met standard criteria for IV thrombolysis were treated with an IV/IA approach. Three-month modified Rankin Scale scores were 0 to 2 for 50% of patients, mortality was 18%, and symptomatic intracerebral hemorrhage occurred in 8%. IV/IA thrombolysis appeared safe and effective in this group.
Publication types
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Clinical Trial
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Comparative Study
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Brain Ischemia / drug therapy*
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Cerebral Angiography
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Cerebral Hemorrhage / chemically induced
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Female
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Fibrinolytic Agents / administration & dosage*
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Fibrinolytic Agents / adverse effects
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Fibrinolytic Agents / therapeutic use
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Humans
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Infusions, Intravenous
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Injections, Intra-Arterial
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Injections, Intravenous
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Male
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Middle Aged
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Plasminogen Activators / administration & dosage*
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Plasminogen Activators / adverse effects
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Plasminogen Activators / therapeutic use
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / adverse effects
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Recombinant Proteins / therapeutic use
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Thrombolytic Therapy / adverse effects
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Thrombolytic Therapy / methods*
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Treatment Outcome
Substances
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Fibrinolytic Agents
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Recombinant Proteins
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Plasminogen Activators