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Oral clopidogrel load in aspirin-resistant capsular warning syndrome

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Abstract

Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation.

Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel.

Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction.

Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

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Authors and Affiliations

  1. Stroke Program, Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine of Northwestern University, 710 North Lake Shore Drive, Abbott Hall 11th Floor, 60611, Chicago, IL

    Christopher D. Fahey, Mark J. Alberts & Richard A. Bernstein

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  1. Christopher D. Fahey
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  2. Mark J. Alberts
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  3. Richard A. Bernstein
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Correspondence to Richard A. Bernstein.

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Fahey, C.D., Alberts, M.J. & Bernstein, R.A. Oral clopidogrel load in aspirin-resistant capsular warning syndrome. Neurocrit Care 2, 183–184 (2005). https://doi.org/10.1385/NCC:2:2:183

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