Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio Predicts Lipid-Rich Coronary Plaque in Patients With Coronary Artery Disease – Integrated-Backscatter Intravascular Ultrasound Study –

Takumi Kimura; Tomonori Itoh; Tetsuya Fusazaki; Hiroki Matsui; Shoma Sugawara; Yoshinobu Ogino; Hiroshi Endo; Ken Kobayashi; Motoyuki Nakamura

doi:10.1253/circj.CJ-09-0849

Ischemic Heart Disease

Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio Predicts Lipid-Rich Coronary Plaque in Patients With Coronary Artery Disease

– Integrated-Backscatter Intravascular Ultrasound Study –

Takumi Kimura, Tomonori Itoh, Tetsuya Fusazaki, Hiroki Matsui, Shoma Sugawara, Yoshinobu Ogino, Hiroshi Endo, Ken Kobayashi, Motoyuki Nakamura

Author information

Takumi Kimura
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Tomonori Itoh
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Tetsuya Fusazaki
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Hiroki Matsui
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Shoma Sugawara
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Yoshinobu Ogino
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Hiroshi Endo
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Ken Kobayashi
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University
Motoyuki Nakamura
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University

Keywords: Coronary artery disease, Integrated-backscatter intravascular ultrasound, Low-density lipoprotein/high-density lipoprotein-cholesterol

JOURNAL FREE ACCESS

2010 Volume 74 Issue 7 Pages 1392-1398

DOI https://doi.org/10.1253/circj.CJ-09-0849

View "Advance Publication" version (May 18, 2010).

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Abstract

Background: The relationship between blood lipid profile and coronary plaque tissue characteristics, and differences in the tissue characteristics between acute coronary syndrome (ACS) and chronic coronary artery disease (CCAD) are unclear. The purpose of the present study was to compare the plaque tissue characteristics in patients with ACS and CCAD and to examine the relationship between the tissue characteristics and blood lipid profile. Methods and Results: Integrated backscatter intravascular ultrasound (IVUS) and conventional IVUS were performed in patients with ACS (n=24) and CCAD (n=68) at the time of coronary intervention. Percent tissue volume and cross-section area of lipid pool, fibrous tissue, dense fibrous and calcification were defined in target lesions. The lipid pool area (LPA) in the ACS patients was significantly higher than in the CCAD patients (LPA, 7.0±3.4 vs 5.1±3.2 mm², P=0.01). In the CCAD group, LPA/non-LPA ratio tended to be higher in the ACS than in the CCAD patients (1.4±0.9 vs 1.1±0.8; P=0.08), and LDL/HDL ratio was an independent predictor for LPA/non-LPA ratio (P=0.002). In addition, LDL/HDL ratio was a useful index for the prediction of a high LPA/non-LPA ratio (area under the receiver operating characteristic curve = 0.79).Conclusions: Elevated LDL/HDL ratio may be a positive predictor for coronary lipid-rich plaque and plaque vulnerability in patients with CCAD. (Circ J 2010; 74: 1392 - 1398)

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