Original ArticleHypoalbuminemia Predicts Acute Stroke Mortality: Paul Coverdell Georgia Stroke Registry
Section snippets
Hospital Selection
The Paul Coverdell Georgia Stroke Registry (PCGSR) was one of 4 sites initially funded by the Centers for Disease Control and Prevention in 2001 to design and implement a registry prototype. Hospital selection was intended to create a representative sample from the state. In Georgia, approximately one third of the hospitals were randomly selected using a simple random sampling procedure.18 The 8 largest hospitals in the state, in terms of stroke volume, were selected with certainty. Of the
Results
There were 1477 consecutively admitted patients identified with an acute cerebrovascular event meeting entry criteria from the 34 hospitals participating in the PCGSR across the state of Georgia (Fig 1). Frequency of stroke types were as follows: acute ischemic stroke (63%), transient ischemic attack (19%), ICH (9%), and SAH (3%). Of cases, 6% were classified as hemorrhages or strokes of undetermined type.
Discussion
This analysis evaluated factors predicting inhospital mortality in a biracial cohort of patients admitted to a representative sample of hospitals in the state of Georgia, a region of the United States that is disproportionately affected by stroke.20
In this group of patients, decreased serum albumin was an independent predictor of mortality in patients admitted for acute stroke. Older age and stroke type (ischemic v hemorrhagic) were also independent predictors of mortality in the multivariate
Conclusions
We report for the first time hypoalbuminemia as an independent predictor of mortality during hospitalization for acute stroke in a representative cohort of patients from a state located in the middle of the stroke belt. We propose that routine serum albumin measurement for determination of hypoalbuminemia be included in factors used early in hospitalization to stratify patients at high risk for inhospital mortality after acute stroke. Additional studies should be taken to determine whether
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Serum Albumin, Body Mass Index, and Preceding Xa and P2Y12 Inhibitors Predict Prognosis of Recurrent Ischemic Stroke
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2020, Annales de Cardiologie et d'AngeiologieCitation Excerpt :In another retrospective study that focused on 336 patients with infective endocarditis scheduled for surgical management, hypoalbuminemia predicted early mortality (P = 0.04) after adjustment for several confounders such as inflammatory markers [68]. Numerous studies have also clearly established the prognostic relevance of hypoalbuminemia in stroke patients [15,70–72]. In a multicenter study that included 1477 consecutive patients with acute stroke, low serum albumin was a strong, independent predictor of in-hospital mortality (P < 0.001) [72].
Collagen-Induced Platelet Aggregates, Diabetes, and Aspirin Therapy Predict Clinical Outcomes in Acute Ischemic Stroke
2019, Journal of Stroke and Cerebrovascular DiseasesSpontaneous Micro-Aggregation of Platelets Predicts Clinical Outcome in Acute Ischemic Stroke
2018, Journal of Stroke and Cerebrovascular DiseasesHuman serum albumin in cardiovascular diseases
2018, European Journal of Internal MedicineCitation Excerpt :Hypoalbuminemia emerged as a strong prognosticator (p < 0.001) in multivariable analysis, after adjusting for renal disease (p = 0.04) and hospitalization at the time of listing (p < 0.01). Large evidence is that hypoalbuminemia is a strong, independent prognostic factor in patients with stroke [21,54–56]. All these observational studies strongly support the prognostic relevance of serum albumin in stroke independent of specific, well-established prognostic factors.
Serum albumin and cardiovascular diseases: A comprehensive review of the literature
2018, Annales de Cardiologie et d'Angeiologie
The Paul Coverdell Georgia Stroke Registry Pilot Prototype is supported by Centers for Disease Control and Prevention Cooperative Agreement No. U50/CCU420275-01. Principal Investigator: Michael R. Frankel.