Developmental Cell
Volume 21, Issue 2, 16 August 2011, Pages 288-300
ArticleNotch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase
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Graphical Abstract
Highlights
► Notch induces transcription of the NO receptor, soluble guanylyl cyclase (sGC) ► Notch also induces transcription of Activin A, which activates eNOS via PI3K/Akt ► Endocardial NO/sGC signaling promotes EndMT and cardiac cushion cellularization
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Present address: Department of Obstetrics and Gynecology, Department of Oncology, and Faculty of Medicine and Dentistry, University of Alberta, Edmonton AB T6G 1Z2, Canada
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