MiscellaneousAssociation of Multiple Inflammatory Markers with Carotid Intimal Medial Thickness and Stenosis (from the Framingham Heart Study)
Section snippets
Participants and covariates
The selection criteria and design of the Framingham Heart Study have been detailed.11 Participants attending the sixth (1996 to 1998) and seventh (1998 to 2001) examination cycles were eligible for this investigation. There were 3,532 participants in the Offspring Cohort study at examination cycle 6, of whom 3,407 (96%) underwent B-mode carotid ultrasonography. Among those with carotid ultrasonography, 2,885 men and women also had serum inflammatory markers (CRP, interleukin-6 [IL-6],
Results
The mean age of the 2,885 eligible participants (53% women) was 59 years at examination cycle 6, when the carotid measures were assessed. Additional clinical characteristics as well as distributions of carotid measures and inflammatory markers are listed in Table 1.
In the multimarker model, we found that the 6 inflammatory markers as a group were significantly associated with ICA-IMT (p = 0.01; Table 2), although they accounted only for an additional 0.5% of the variability in ICA-IMT. The 6
Discussion
In our large community-based cohort, we examined the relations of a panel of 6 inflammatory markers with measures of carotid atherosclerosis. In the multivariate-adjusted multimarker model, inflammatory markers as a group were found to be associated with ICA-IMT. Further examination of individual markers revealed that CRP and IL-6 were positively related to ICA-IMT, and IL-6 was positively associated with carotid stenosis.
Our findings confirm and extend our previous report of a significant
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2017, Biomedical JournalCitation Excerpt :Third, NC was displayed to be the strongest predictor of severe NIHSS, highlighting that NC should be considered as a useful auxiliary biomarker for more intensive care and pharmacomodulation as well as the application of beneficially invasive intervention for improving neurological function and clinical outcome. Abundant data have shown that NC and NLR are stronger inflammatory mediators than white blood cells (WBC) in various diseases [17,18,25–27]. Of interest, NC and NLR are not only inflammatory mediators but have also emerged as important biomarkers for predicting adverse clinical outcomes in various clinical settings, such as in solid tumors [27], atrial fibrillation [28], non-ST segment elevation myocardial infarction (non-STEMI) [29] and STEMI [19–21] undergoing primary PCI.
This study was supported by Contract N01-HC-25195 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Dr. Benjamin was supported by Grants HL64753 and 1 RO1 HL076784, Dr. Keaney by Grants DK55656 and HL60886, Dr. Vasan by Grant HL70139, and Dr. Wang by Grant HL074077 from the National Institutes of Health, Bethesda, Maryland. Dr. Vasan is the recipient of Research Career Award HL04334 from the National Institutes of Health.