Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model**
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Cited by (112)
Intracerebral hemorrhage in translational research
2020, Brain HemorrhagesPreterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
2018, Volpe's Neurology of the NewbornAnimal Models for the Study of Neonatal Disease
2017, Animal Models for the Study of Human Disease: Second EditionPost-hemorrhagic hydrocephalus: Recent advances and new therapeutic insights
2017, Journal of the Neurological SciencesCitation Excerpt :Foremost, in this model, hemorrhage generally begins with the rupture of blood vessels within the germinal-matrix, with subsequent extension into ventricles to eventually form hydrocephalus in a manner morphologically similar to premature infants [109]. Additionally, this model employing rats is far less expensive and less labor-intensive compared with models using piglets, beagles or rabbits [102,103,106]. Therefore, this model can be adapted to examine strategies for the prevention and treatment of post-hemorrhagic complications, especially for PHH following GMH.
Intracerebral hemorrhage associated with oral phenylephrine use: A case report and review of the literature
2014, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Our case had angiographic evidence of RCVS further supporting the etiology of her ICH from PHE-induced RCVS. Phenylephrine (Fig 3) has similar pharmacologic characteristics and side effects to other adrenaline-like sympathomimetics4 and prior published case reports1,12-17 and animal studies18,19 suggest a relationship between administration—intravenous, intranasal, and topical—and occurrence of stroke. We performed a review of the literature to identify cases of stroke attributed to PHE use.
Progress in translational research on intracerebral hemorrhage: Is there an end in sight?
2014, Progress in NeurobiologyCitation Excerpt :The iron-handling proteins heme-oxygenase-1 and ferritin are up-regulated after IVH and treatment with the iron chelator deferoxamine decreases post-IVH ventricular enlargement. Spontaneous IVH has been induced in neonatal animal models after hypertension in the newborn beagle (Goddard et al., 1980; Litrico et al., 2013) and after hypotension followed by volume expansion in a beagle puppy model (Ment et al., 1982). Spontaneous IVH has also been induced in premature rabbits (Chua et al., 2009; Lorenzo et al., 1982).
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Presented to the members of the Child Neurology Society at their Eighth Annual Meeting, September 13 to 15, 1979, Hanover, New Hampshire.
- 1
Dr. Goddard supported by a grant from the Walter Scott Foundation, New York City, New York.
- 2
Mr. Lewis supported in part by Grant No. HL 17269. National Heart and Blood Vessel Research and Demonstration Center, Baylor College of Medicine.