When neoangiogenesis ricochets☆,☆☆,★
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Cited by (47)
Dynamic change of carotid intraplaque hemorrhage volume in subjects with mild carotid stenosis
2018, European Journal of RadiologyHistopathology of cardiovascular thrombus
2018, Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and InterventionsEx Vivo Porcine Arterial and Chorioallantoic Membrane Acoustic Angiography Using Dual-Frequency Intravascular Ultrasound Probes
2016, Ultrasound in Medicine and BiologyCitation Excerpt :As atherosclerotic plaques develop, vasa vasorum extend through the media and intimal layers into the plaques themselves (Barger et al. 1984). These intraplaque vessels often have incomplete endothelial linings and lack smooth muscle cell support, making them vulnerable to hemorrhage within the plaque, which is associated with advanced disease progression as the plaque further destabilizes (Kolodgie et al. 2003; Virmani et al. 1998). With additional plaque buildup, a state of arterial stenosis and ischemia develops, which is a more advanced stage of disease commonly associated with increased symptoms and complications (Naghavi et al. 2003).
Pathophysiology of atherosclerosis plaque progression
2013, Heart Lung and CirculationDifferent stages of intraplaque hemorrhage are associated with different plaque phenotypes: A large histopathological study in 794 carotid and 276 femoral endarterectomy specimens
2011, AtherosclerosisCitation Excerpt :Most intraplaque neovessels arise from the adventitial vasa vasorum. Adventitial vasa vasorum demonstrate complete maturation, whereas newer branches that transverse the medial layer into the intima are more fragile and leaky [31]. These leaky vessels are characterized by defects between endothelial junctions resulting in diffuse perivascular expression of von Willebrand factor (vWF) as a sign of less intact or leaky endothelium [4,5,32].
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From the Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, and Allegheny University of the Health Sciences.
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Reprint requests: Renu Virmani, MD, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306-6000.
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