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Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway

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Abstract

The present study was to determine the preventive effect of resveratrol (Res) on diabetes-induced cardiac dysfunction and the possible signaling pathway involved. Diabetes was induced in rats by injection of streptozotocin (STZ) at 45 mg/kg. The animals were randomly divided into three groups (10 rats/group): normal group, diabetes groups with or without Res (80 mg/kg) treatment. Biochemistry, cardiac function and fibrosis were detected. Moreover, pro-inflammatory cytokines were evaluated, and heart tissues were homogenized for western blot analysis to analyze the possible mechanisms. The results indicated that Res might regulate glucose and lipid metabolism, ameliorate cardiac function and fibrosis response in STZ-induced diabetic rats. The protective effects were consistent with the inhibition of inflammatory factors such as TNF-α, IL-6 and IL-1β. In addition, Res favorably shifted STZ-induced AT1R, ERK1/2 and p38 MAPK activation in rat heart. In conclusion, the results suggested that Res attenuated diabetes-induced cardiac dysfunction, and the effects were associated with attenuation inflammatory response and down-regulation of AT1R-ERK/p38 MAPK signaling pathway.

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Acknowledgments

This work was supported by the Natural Science Foundation of Shandong Province (No. ZR2014JL048) and National Natural Science Foundation of China (No. 20973149).

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Authors and Affiliations

  1. School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People’s Republic of China

    Yonglin Gao, Le Kang, Xiaoyan Wang, Chengfeng Sun & Qingzhong Li

  2. School of Pharmacy, Yantai University, Yantai, 264005, Shandong, People’s Republic of China

    Chunmei Li

  3. Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, People’s Republic of China

    Ruihua Liu & Jianping Wang

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  1. Yonglin Gao
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  2. Le Kang
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  5. Chengfeng Sun
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  6. Qingzhong Li
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Correspondence to Chunmei Li or Jianping Wang.

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Gao, Y., Kang, L., Li, C. et al. Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway. Cardiovasc Toxicol 16, 130–137 (2016). https://doi.org/10.1007/s12012-015-9321-3

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  • DOI: https://doi.org/10.1007/s12012-015-9321-3

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