Summary
A study has been made of the cerebral blood flow (CBF) in moyamoya disease from the perspective of hemispheric cerebral blood flow and regional CBF (rCBF). The material includes 21 children between the ages of 5 and 15 years with moyamoya disease, and 19 adult moyamoya cases-all of which had virtually no neurological symptoms at the time of the study. CBF was measured using the133Xe intravenous injection method. Comparsion was made with the measurements from 16 normal children and 14 normal adults. Study was also made of the relationship between the angiographic stage of the disease and the CBF.
With the exception of the more elderly patients, CBF was found to be significantly lower in the moyamoya cases than in normal subjects of the same age group. In all age groups, the distribution of rCBF showed a dominant posterior distribution, dissimilar to the dominant anterior distribution found in the normals. Among the juvenile moyamoya cases, there was a tendency toward decreasing hemispheric blood flow together with advancing disease-as determined angiographically. Moreover, with advancing stages of the disease, there was a continuing transition from the normal pattern of frontal dominance to one of occipital dominance. This dominance of posterior rCBF is thought to be a characteristic feature of moyamoya disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Isono M, Yonemitsu T, Fujiwara S, Kodama N, Suzuki J (1981) Epidemiological study on moyamoya disease. From the experiences of 100 cases. In: Prodeeding of the 10th Japanese Conference on Surgery for Cerebral Stroke. Neuron, Tokyo, pp 3–7
Kameyama M, Sirane R, Tsurumi Y, Takahasi A, Fujiwara S, Suzuki J, Ito M, Ido T (1986) Evaluation of cerebral blood flow and metabolism in childhood moyamoya disease: an investigation into “re-build-up” on EEG by positron CT. Child's Nerve Syst 2: 130–133
Karasawa J, Kikuchi H, Kuriyama Y, Sawada T, Ban M, Kobayashi K, Koike T, Mitsuki T (1981) Cerebral hemodynamics in “Moyamoya” disease-II. Measurement of cerebral circulation and metabolism by use of the argon desaturation method in pre- and postneurosurgical procedures. Neurol Med Chir (Tokyo) 21: 1161–1168
Mizukawa N (1975) Moyamoya disease-its symptoms and etiology. Blood Vessel (Tokyo) 6: 937–945
Nishimoto A (1979) Moyamoya disease (a disease with abnormal vascular networks at the base of the brain). Neurol Med Chir (Tokyo) 19: 221–228
Nishimoto A, Onbe H, Ueta K (1979) Clinical and cerebral blood flow study in moyamoya disease with TIA. Acta Neurol Scand 60 [Suppl 72]: 434–435
Ogawa A, Kogure T, Fujiwara S, Kodama N, Suzuki J, Sakurai T, Wada T (1981) Regional cerebral blood flow on moyamoya disease. Study with 133Xe intravenous injection method. In: Prodeeding of the 10th Japanese Conference on Surgery for Cerebral Stroke. Neuron, Tokyo, pp 189–194
Ogawa A, Yoshimoto T, Sakurai Y, Kayama T (1989) Regional cerebral blood flow in children. Normal values and regional distribution of cerebral blood flow. Neurol Res 11: 173–176
Suzuki J, Takaku A, Asahi M, Kowada M (1965) Diseases showing the “fibrille” like vessels at the base of the brain. Frequently found in Japan. Brain Nerve (Tokyo) 17: 767–776
Suzuki J, Takaku A, Asahi M (1966) The disease showing the abnormal vascular network at the base of the brain, particulars found in Japan. II. A follow-up study. Brain Nerve (Tokyo) 18: 897–908
Suzuki J, Takaku A (1969) Cerebrovascular moyamoya disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol 20: 288–299
Suzuki J (1986) Moyamoya disease. Springer, Berlin Heidelberg New York
Suzuki R, Tsuruoka S, Hiratsuka H, Matsushima Y, Fukumoto T, Inaba Y, Ohno K (1985) Cerebral circulation in pediatric patients with moyamoya disease. Tomographic cerebral blood flow obtained by Xenon-enhanced computerized tomography. Neurol Med Chir (Tokyo) 25: 969–974
Takahashi S, Kutsuzawa T, Takahashi S (1967) Studies on cerebral hemodynamics. In: Kudo T (ed) A disease with abnormal intracranial vascular networks. Spontaneous occlusion of the circle of Willis. Igaku shoin, Tokyo, pp 35–37
Takahashi A, Fujiwara S, Suzuki J (1986) Long-term follow up angiography of moyamoya disease. Cases follow up from childhood to adolescence. Neurol Surg (Tokyo) 14: 23–29
Uemura K, Yamaguchi K, Kojima S, Sakurai Y, Ito Z, Kawakami H, Kutsuzawa T (1975) Regional cerebral blood flow on Cerebrovascular “Moyamoya” disease. Study by133Xe clearance method and cerebral angiography. Brain Nerve (Tokyo) 27: 385–393
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogawa, A., Yoshimoto, T., Suzuki, J. et al. Cerebral blood flow in moyamoya disease. Acta neurochir 105, 30–34 (1990). https://doi.org/10.1007/BF01664854
Issue Date:
DOI: https://doi.org/10.1007/BF01664854