Matrix metalloproteinases (MMPs) that are either upregulated or downregulated after focal cerebral ischaemia and reperfusion in rats and mice
| Gene | Δ Fold over sham in rats | Δ Fold over sham in mice |
| MMP-1a | No change | −13.08 |
| MMP-2 | No change | 11.12 |
| MMP-3 | 11.28 | No change |
| MMP-8 | No change | 279.55 |
| MMP-9 | 16.05 | 24.39 |
| MMP-10 | No change | −247.83 |
| MMP-12 | 47.15 | 763.79 |
| MMP-15 | No change | −22.33 |
| MMP-16 | No change | −29.74 |
| MMP-17 | No change | −32.47 |
| MMP-21 | No change | −53.60 |
Focal cerebral ischaemia was induced for 2 hours in rats and 1 hour in mice. Changes in mRNA expression of various MMPs in the ischaemic brain of rats versus mice were analysed 1 day after reperfusion. MMPs that were either upregulated or downregulated significantly (P<0.05) and more than 10-fold as compared with their respective sham-operated rats10 and mice are included in this table and those with less than 10-fold change are indicated as ‘no change’. A positive value indicates upregulation and a negative value indicates downregulation. n=6.