Table 2

Matrix metalloproteinases (MMPs) that are either upregulated or downregulated after focal cerebral ischaemia and reperfusion in rats and mice

GeneΔ Fold over sham in ratsΔ Fold over sham in mice
MMP-1aNo change−13.08
MMP-2No change11.12
MMP-311.28No change
MMP-8No change279.55
MMP-10No change−247.83
MMP-15No change−22.33
MMP-16No change−29.74
MMP-17No change−32.47
MMP-21No change−53.60
  • Focal cerebral ischaemia was induced for 2 hours in rats and 1 hour in mice. Changes in mRNA expression of various MMPs in the ischaemic brain of rats versus mice were analysed 1 day after reperfusion. MMPs that were either upregulated or downregulated significantly (P<0.05) and more than 10-fold as compared with their respective sham-operated rats10 and mice are included in this table and those with less than 10-fold change are indicated as ‘no change’. A positive value indicates upregulation and a negative value indicates downregulation. n=6.