Comparison of baseline characteristics among the RCIR, RIR, RCR and NRR groups
| Characteristic | RCIR n=46 | RIR n=211 | RCR n=107 | NRR n=588 | P value |
| Age, mean±SD, years | 59.38±8.36 | 59.75±8.44 | 59.57±8.53 | 59.45±8.47 | 0.889 |
| Male, n (%) | 38 (82.6%) | 178 (84.8%) | 79 (73.8%) | 456 (77.6%) | 0.071 |
| BMI (kg/m2), median (IQR) | 26.07±3.58 | 26.43±3.54 | 25.84±2.74 | 25.80±2.91 | 0.083 |
| Hypertension, n (%) | 37 (80.4%) | 181 (85.8%) | 76 (71%) | 462 (78.6%) | 0.018 |
| Diabetes mellitus, n (%) | 22 (47.8%) | 83 (39.3%) | 38 (35.5%) | 232 (39.5%) | 0.563 |
| Hypercholesterolaemia, n (%) | 26 (56.5%) | 149 (70.6%) | 76 (71%) | 391 (66.5%) | 0.228 |
| Coronary artery disease, n (%) | 7 (15.2%) | 28 (13.3%) | 24 (22.4%) | 88 (15%) | 0.182 |
| Smoking, n (%) | 31 (67.4%) | 140 (66.4%) | 57 (53.3%) | 343 (58.3%) | 0.063 |
| Qualifying events, n (%) | 0.619 | ||||
| Stroke | 31 (67.4%) | 158 (74.9%) | 74 (69.2%) | 424 (72.1%) | |
| TIA | 15 (32.6%) | 53 (25.1%) | 33 (30.8%) | 164 (27.9%) | |
| NIHSS, median (IQR) | 0 (0, 1) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0.140 |
| mRS, n (%) | 0.260 | ||||
| 0 | 26 (56.5%) | 120 (56.9%) | 66 (61.7%) | 326 (58.5%) | |
| 1 | 16 (34.8%) | 57 (27%) | 29 (27.1%) | 190 (32.3%) | |
| 2 | 3 (6.5%) | 20 (9.5%) | 9 (8.4%) | 57 (9.7%) | |
| 3 | 1 (2.2%) | 14 (6.6%) | 3 (2.8%) | 15 (2.6%) | |
| LDL-C (mmol/L), median (IQR) | 2.99 (2.81–3.47) | 1.76 (1.37–2.08) | 3.00 (2.77–3.42) | 1.72 (1.43–2.08) | <0.001 |
| HDL-C (mmol/L), median (IQR) | 1.01 (0.91–1.15) | 0.88 (0.76–1.01) | 1.10 (0.95–1.27) | 0.98 (0.82–1.12) | <0.001 |
| hs-CRP (mg/L), median (IQR) | 5.75 (4.25–11.45) | 7.30 (4.50–11.40) | 1.19 (0.62–1.90) | 0.90 (0.40–1.60) | <0.001 |
| Time from laboratory testing to stenting (days), median (IQR) | 3.50 (2.00–5.25) | 4 (2–6) | 4 (3–7) | 4 (2–6) | 0.132 |
| Number of CYP2C19 genotyping | 6 (13.0%) | 40 (19.0%) | 26 (24.3%) | 111 (18.9%) | 0.398 |
| Number of CYP2C19 loss-of-function carriers | 5 (83.3%) | 25 (62.5%) | 14 (53.8%) | 67 (60.4%) | 0.602 |
BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; NRR, no residual risk; RCIR, residual cholesterol inflammatory risk; RCR, residual cholesterol risk; RIR, residual inflammatory risk; TIA, transient ischaemic attack.