Table 3

Association between tHcy and intracranial aneurysm

	Before matched						After matched
	Crude OR		Model 1*		Model 2†		Crude OR		Model 1*		Model 2†
	Crude OR		Adjusted OR		Adjusted OR		Crude OR		Adjusted OR		Adjusted OR
	95% CI	P	95% CI	P	95% CI	P	95% CI	P	95% CI	P	95% CI	P
tHcy‡ (SD), μmol/L	1.23 (1.18 to 1.28)	<0.001	1.50 (1.43 to 1.57)	<0.001	1.50 (1.43 to 1.57)	<0.001	1.82 (1.70 to 1.95)	<0.001	1.99 (1.85 to 2.13)	<0.001	1.98 (1.85 to 2.14)	<0.001
tHcy§	1.13 (1.11 to 1.16)	<0.001	1.30 (1.24 to 1.33)	<0.001	1.29 (1.25 to 1.33)	<0.001	1.44 (1.38 to 1.50)	<0.001	1.51 (1.45 to 1.59)	<0.001	1.52 (1.45 to 1.59)	<0.001
Group tHcy, number (%)								<0.001¶		<0.001¶		<0.001¶
Low	Reference.		Reference.		Reference.		Reference.		Reference.		Reference.
Moderate	1.38 (1.27 to 1.49)	<0.001	1.72 (1.47 to 2.00)	<0.001	1.71 (1.61 to 1.82)	<0.001	2.13 (1.93 to 2.36)	<0.001	2.70 (2.19 to 3.37)	<0.001	1.80 (1.67 to 1.94)	<0.001
High	1.97 (1.60 to 2.42)	<0.001	0.94 (0.85 to 1.05)	0.281	2.06 (1.76 to 2.40)	<0.001	3.66 (2.71 to 4.95)	<0.001	0.90 (0.78 to 1.04)	0.200	2.69 (2.17 to 3.34)	<0.001
Moderate+high	1.43 (1.32 to 1.54)	<0.001	1.59 (1.50 to 1.69)	<0.001	2.20 (2.02 to 2.39)	<0.001	2.24 (2.03 to 2.47)	<0.001	1.88 (1.75 to 2.02)	<0.001	1.87 (1.74 to 2.00)	<0.001

P-value for OR (odd ratios) was based on Wald tests.
*Adjusted for age, sex, hypertension and smoking.
†Adjusted for variables from Model 1 plus dyslipidaemia and diabetes.
‡: OR was estimated by one standard difference increase of tHcy (8.2 µmol/L).
§: OR was estimated by a increase of 5 µmol/L of tHcy.
¶: P value for trend.
tHcy, total homocysteine.