Table 3

Interaction between TM and thrombectomy-alone or combination-therapy on the clinical outcomes

TMAdjusted
value
NTMAdjusted valueP for interaction
Thrombectomy- alone (n=20)Combination therapy (n=48)Thrombectomy- alone
(n=289)
Combination therapy
(n=267)
mRS 90days (IQR)2 (0–4.5)3 (1.5–5)1.584 (0.595, 4.217)3 (2–5)4 (2–5)1.111 (0.827,1.473)0.687
mRS (0–1)9 (45.00%)12 (25.00%)2.559 (0.688, 9.519)67 (23.30%)56 (21.00%)1.167 (0.763,1.785)0.438
mRS (0–2)11 (55.00%)22 (45.83%)1.024 (0.275, 3.807)101 (35.07%)93 (34.83%)1.052 (0.718,1.540)0.955
Death3 (15.00%)7 (14.58%)1.180 (0.221, 6.306)54 (18.7%)51 (19.1%)0.938 (0.602,1.463)0.602
SNI at day7 or discharge12 (60.00%)27 (56.3%)1.361 (0.414, 4.473)156 (54.0%)146 (54.7%)0.988 (0.696,1.402)0.899
eTICI on final angiogram≥2b15 (75.00%)42 (89.4%)0.190 (0.037, 0.965)225 (79.5%)221 (83.7%)0.757 (0.489,1.173)0.259
Outcome lesion volume on CT—median (IQR)—mL21.99 (2.38,91.11)32.11 (9.57, 83.35)16.791 (−32.481, 66.063)37.15 (10.07, 114.77)39.45 (10.53, 101.84)0.447 (−13.821, 14.715)0.512
NIHSS score at 5–7 days or discharge—median (IQR)3.00 (0.50, 11.00)5.00 (1.00, 12.00)1.081 (−5.636, 7.799)8.00 (2.00, 17.00)9.00 (2.00,19.00)−1.475 (−3.540, 0.580)0.299
EQ-5D score at 90 days—median (IQR)0.94 (0.57, 1.00)0.95 (0.75, 1.00)0.057 (−0.164, 0.278)0.84 (0.33, 0.95)0.84 (0.33, 0.95)0.018 (−0.062, 0.093)0.899
Vascular dissection0.00 (0.00)0.00 (0.00%)8 (2.80%)5 (1.90%)1.597 (0.512,4.986)0.998
Symptomatic ICH2 (10.00%)2 (4.20%)3.462 (0.318, 37.735)12 (4.20%)18 (6.70%)0.580 (0.272, 1.236)0.127
Asymptomatic ICH1 (5.00%)16 (33.30%)0.118 (0.014, 0.996)104 (36.00%)102 (38.20%)0.919 (0.647, 1.307)0.054
Embolism in new area0.00 (0.00%)2 (4.20%)0.000 (0.000, 2.263)35 (12.10%)29 (10.90%)1.107 (0.648, 1.892)0.951
  • *Values were adjusted for baseline NIHSS score, mRS score before stroke, cerebral collateral blood-flow status, time from stroke onset to randomisation reported.

  • EQ-5D, EuroQol-5 Dimension; eTICI, expanded thrombolysis in cerebral infarction grading system; ICH, intracranial haemorrhage; mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale Score; SNI, significant neurological improvement; TM, thrombus migration.