The association between SLE and risk of stroke events
| Variables | Ischaemic stroke | Haemorrhage stroke | Stroke | |||
| aHR (95% CI) | P value | aHR (95% CI) | P value | aHR (95% CI) | P value | |
| SLE | 1.65 (1.45 to 1.87) | <0.001 | 2.24 (1.71 to 2.95) | <0.001 | 1.73 (1.54 to 1.94) | <0.001 |
| Age | ||||||
| 18–30 (ref) | 1.00 | 1.00 | 1.00 | |||
| 31–40 | 1.48 (1.15 to 1.92) | 0.003 | 1.18 (0.76 to 1.83) | 0.471 | 1.42 (1.14 to 1.78) | 0.002 |
| 41–50 | 3.29 (2.62 to 4.14) | <0.001 | 2.06 (1.37 to 3.11) | 0.001 | 2.81 (2.29 to 3.44) | <0.001 |
| >50 | 8.71 (7.06 to 10.74) | <0.001 | 3.53 (2.4 to 5.20) | <0.001 | 7.28 (6.06 to 8.76) | <0.001 |
| Gender | ||||||
| Female (ref) | 1.00 | 1.00 | 1.00 | |||
| Male | 1.32 (1.12 to 1.56) | 0.001 | 1.56 (1.10 to 2.21) | 0.012 | 1.33 (1.14 to 1.55) | <0.001 |
| CCI | ||||||
| 0 (ref) | 1.00 | 1.00 | 1.00 | |||
| 1 | 1.20 (1.03 to 1.40) | 0.019 | 1.01 (0.73 to 1.40) | 0.968 | 1.19 (1.04 to 1.37) | 0.014 |
| 2 | 1.09 (0.89 to 1.33) | 0.001 | 1.06 (0.69 to 1.62) | 0.801 | 1.16 (0.97 to 1.39) | 0.113 |
| ≥3 | 1.61 (1.34 to 1.94) | <0.001 | 1.26 (0.82 to 1.94) | 0.295 | 1.61 (1.36 to 1.92) | <0.001 |
| Urbanisation | ||||||
| Urban (ref) | 1.00 | 1.00 | 1.00 | |||
| Suburban | 1.11 (0.93 to 1.34) | 0.258 | 0.96 (0.64 to 1.44) | 0.835 | 1.10 (0.93 to 1.30) | 0.284 |
| Rural | 1.12 (0.97 to 1.30) | 0.120 | 0.90 (0.65 to 1.24) | 0.514 | 1.11 (0.97 to 1.27) | 0.137 |
| Antithrombotic | ||||||
| No (ref) | 1.00 | 1.00 | 1.00 | |||
| Yes | 2.14 (1.88 to 2.47) | <0.001 | 1.98 (1.46 to 2.67) | <0.001 | 2.16 (1.9 to 2.45) | <0.001 |
aHR, adjusted HR; CCI, Charlson Comorbidity Index; SLE, systemic lupus erythematosus.