Table 2

Assessment schedule

Visit	Visit 1	Visit 2	Visit 3	Visit 4	Visit 5	Visit 6 Telephone interview	Visit 7	Follow-up 1 year to 3 years (Visit 8, 9, 10, 11)
Assessment	Baseline15 days～0 day	Angiogram 0 day	Discharge	30 days±7 days	90 days±7 days	6 months±14 days	1 year±30 days	6 months intervals
Informed consent	√
Inclusion/exclusion criteria check	√
History and physical examination	√
Vital signs*	√	√	√	√	√		√
Blood laboratory test† and urine routine test	√		√	√	√		√
Coagulation function‡	√
FBG, HbA1c§	√			√	√		√
Platelet aggregation test and/or CYPC219 genotype test¶	√
ECG	√
MRI/CT	√						√
CTP**	√				√		√
DSA/CTA/MRA	√						√
Life-style modification review††	√		√	√	√	√	√	√
mRS	√			√	√	√	√	√
NIHSS (neurological examination) examination)	√		√		√		√
EQ-5D	√						√	√
MoCA¶	√						√	√
HR-VWI,TCD¶	√						√
Medication review and patient compliance survey		√	√	√	√		√
AE, SAE and endpoints‡‡	√	√	√	√	√	√	√	√

*Vital signs: body temperature, blood pressure, respiration rate, heart rate.
†Blood laboratory test includes blood routine and biochemistry examinations, hepatic and renal function tests.
‡Coagulation function: PT, APTT, TT, FIB, INR.
§HbA1c is an optional inspection but is recommended for patients with diabetes mellitus.
¶Platelet aggregation test, CYPC219 genotype test, MoCA, HR-VWI and TCD test are optional according to the actual situation of the centre.
**CTP is an optional inspection, but is recommended for patients with haemodynamic compromise, poor collateral or perforator stroke.
††Life-style modification review: including whether to smoke and the number of cigarettes per day; Weight: reflect the patient’s weight control through the patient’s weight and BMI; Exercise: number of exercises per week and duration of each exercise.
‡‡After 1 year of follow-up, follow-up will focus on AE, SAE and endpoint events;
AE, adverse event; CTA, CT angiography; CTP, CT perfusion; DSA, digital subtraction angiography; ECG, electrocardiograph; EQ-5D, quality-of-life EuroQol-5 Dimensions; FBG, fasting blood glucose; HbA1c, glycosylated haemoglobin; HR-VWI, high-resolution vessel wall imaging; INR, international normalized ratio; MoCA, montreal cognitive assessment; MRA, magnetic resonance angiography; mRS, modified Rankin scale; SAE, serious adverse event; TCD, transcranial Doppler.