Baseline characteristics of study participants with minor stroke (NIHSS <6) treated with tenecteplase and alteplase
| Baseline characteristic | Tenecteplase (N=194) | Alteplase (N=184) |
| Age, median (IQR), years | 72 (62–83) | 71 (59–81) |
| Female sex, N (%) | 75 (38.7) | 75 (40.8) |
| Baseline NIHSS, median (IQR) | 4 (3–5) | 4 (3–5) |
| Baseline ASPECTS score (n=143)†, median (IQR) | 9 (9–10) | 9 (9–10) |
| Intracranial occlusion site on baseline CT angiography (n=376)* | ||
| Internal carotid artery (ICA), N (%) | 3 (1.5) | 0 (0) |
| M1 segment middle cerebral artery (MCA), N (%) | 9 (4.7) | 6 (3.3) |
| M2 segment MCA, N (%) | 42 (21.8) | 17 (9.3) |
| Other distal occlusions (MCA, ACA, PCA)‡, N (%) | 43 (22.3) | 41 (22.4) |
| Vertebrobasilar arterial system, N (%) | 11 (5.7) | 14 (7.6) |
| Cervical ICA, N (%) | 3 (1.5) | 3 (1.6) |
| No visible occlusions, N (%) | 82 (42.5) | 102 (55.7) |
| Presence of large vessel occlusion on baseline CT angiography, N (%) | 13 (6.7) | 6 (3.3) |
| Type of enrolling centre | ||
| Primary stroke centre, N (%) | 14 (7.2) | 8 (4.3) |
| Comprehensive stroke centre, N (%) | 180 (92.8) | 176 (95.6) |
| Workflow times, median (IQR), min | ||
| Stroke symptom onset to randomisation, min | 146 (100–212) | 149 (106–205) |
| Stroke symptom onset to start of thrombolysis, min | 150 (106–218) | 159 (111–214) |
| Baseline CT to arterial puncture (in patients undergoing EVT), min | 78 (58–188) | 95 (51–216) |
| Arterial puncture to successful reperfusion (in patients undergoing EVT), min | 33 (18–41) | 21 (13–25) |
Data are n (%), n/N (%) or median (IQR). Large vessel occlusion is defined as large vessel occlusion of the ICA, M1 segment MCA or functional M1 segment MCA occlusion, that is, all M2 segments MCA occluded on baseline CT angiography scan. If patients had more than one occlusion site, the most proximal occlusion is listed.
*Two patients had baseline non-contrast CT but did not have a baseline CT angiography.
†ASPECTS was available for patients who had ICA or MCA occlusion at baseline.
‡MCA (M3 and beyond), ACA (A2 and beyond) or PCA (P2 and beyond).
ACA, anterior cerebral artery; ASPECTS, Alberta Stroke Program Early CT Score; EVT, endovascular thrombectomy; NIHSS, National Institutes of Health Stroke Scale; PCA, posterior cerebral artery.