Table 1

The baseline characteristics of UK Biobank participants included in the study

Participants characteristicsOverallHealthy control10-year incident CVD
(n=473 611)(n=442 145)(n=31 466)
Age, year57.0 (50–63)57.0 (49.0–63.0)62.0 (57.0–66)
Sex (female)264 308 (55.8%)252 586 (57.1%)11 722 (37.3%)
Ethnicity (white)445 075 (94.0%)415 611 (94.0%)29 464 (93.6%)
Systolic blood pressure (mm Hg)134(123–147)134.0 (122–147)141 (129–155)
Total cholesterol (mmol/L)5.7 (4.99–6.46)5.71 (5.00–6.46)5.63 (4.80–6.48)
HDL cholesterol (mmol/L)1.41 (1.18–1.68)1.42 (1.19–1.69)1.28 (1.09–1.54)
Cholesterol ratio (total/HDL)3.97 (3.37–4.73)3.95 (3.35–4.70)4.3 (3.59–5.09)
Cystatin C (mg/L)0.88 (0.80–0.98)0.88 (0.8–0.97)0.95 (0.86–1.06)
Chest pain24 126 (5.1%)20 107 (4.5%)4019 (10.4%)
Current smoker49 135 (10.4%)44 372 (10.0%)4763 (15.1%)
Pack years of smoking18.4 (9.50–31.0)17.8 (9.0–30.0)25.0 (13.8–39.5)
Cholesterol and blood pressure medication
 Either76 018 (16.1%)67 842 (15.3%)8176 (26.0%)
 Both37 376 (7.9%)31 462 (7.1%)5914 (18.8%)
Number of medications2 (0–3)2.0 (0.0–3.0)3.0 (1.0–5.0)
Angina or heart attack7482 (1.6%)4890 (1.1%)2592 (8.2%)
Diabetes21 601 (4.6%)18 078 (4.1%)3523 (11.2%)
Hypertension38 988 (8.2 %)33 279 (7.5%)5709 (18.1%)
  • Data is presented as median (IQR) for continuous variables and number (%) for discrete variables. Statistics of 10-year incident myocardial infarction, ischaemic stroke and haemorrhagic stroke are shown in online supplemental eTable 3. HDL, high-density lipoprotein.

  • CVD, cardiovascular diseases.