Association of the RNF213 p.R4810K variant with TOAST classification
| TOAST classification | Number (%) | OR (95% CI) | P value | Adjusted OR (95% CI)* | Adjusted P value* | ||
| All patients (N=10 381) | Carriers (n=56) | Non-carriers (n=10 325) | |||||
| LAA | 2652 (25.6) | 22 (39.3) | 2630 (25.5) | 1.90 (1.11 to 3.25) | 0.02 | 1.94 (1.13 to 3.33) | 0.02 |
| CE | 2183 (21.0) | 9 (16.1) | 2174 (21.1) | 0.72 (0.35 to 1.47) | 0.36 | 0.69 (0.34 to 1.41) | 0.31 |
| SVO | 662 (6.4) | 4 (7.1) | 658 (6.4) | 1.13 (0.41 to 3.13) | 0.81 | 1.55 (0.55 to 4.35) | 0.41 |
| Others† | 4884 (47.1) | 21 (37.5) | 4863 (47.1) | 0.67 (0.39 to 1.16) | 0.15 | 0.64 (0.37 to 1.11) | 0.11 |
*Adjusted model: adjusted by age, sex, BMI, smoking status and medical history (hypertension, diabetes mellitus and dyslipidaemia).
†Others were combined by other determined cause and undetermined cause of TOAST classification.
BMI, body mass index; CE, cardioembolism; LAA, large-artery atherosclerosis; SVO, small-vessel occlusion; TOAST, Trial of Org 10172 in Acute Stroke Treatment.