Table 3

Association of the RNF213 p.R4810K variant with large artery stenosis phenotypes

Large artery stenosis phenotypesNumber (%)OR (95% CI)P valueAdjusted OR (95% CI)*Adjusted P value*
All patients (N=9126)Carriers (n=53)Non-carriers (n=9073)
ICAS4275 (46.8)31 (58.5)4244 (46.8)1.60 (0.93 to 2.77)0.091.73 (0.99 to 3.01)0.05
 Anterior2953 (32.4)26 (49.1)2927 (32.3)2.02 (1.18 to 3.47)0.012.12 (1.23 to 3.65)0.007
 Posterior2674 (29.3)13 (24.5)2661 (29.3)0.78 (0.42 to 1.47)0.450.85 (0.45 to 1.61)0.62
 Anterior without posterior1601 (17.5)18 (34.0)1583 (17.5)2.43 (1.38 to 4.01)0.0022.39 (1.35 to 4.24)0.003
 Posterior without anterior1322 (14.5)5 (9.4)1317 (14.5)0.62 (0.25 to 1.55)0.300.65 (0.26 to 1.63)0.36
 Anterior and posterior1352 (14.8)8 (15.1)1344 (14.8)1.02 (0.48 to 2.17)0.951.13 (0.53 to 2.43)0.75
ICAS without ECAS3595 (39.4)26 (49.1)3569 (39.3)1.49 (0.87 to 2.55)0.151.54 (0.90 to 2.66)0.12
 Anterior2508 (27.5)22 (41.5)2486 (27.4)1.88 (1.09 to 3.26)0.021.92 (1.11 to 3.32)0.02
 Posterior2173 (23.8)11 (20.8)2162 (23.8)0.84 (0.43 to 1.63)0.600.89 (0.46 to 1.75)0.74
 Anterior without posterior1422 (15.6)15 (28.3)1407 (15.5)2.15 (1.18 to 3.92)0.012.10 (1.15 to 3.83)0.02
 Posterior without anterior1087 (11.9)4 (7.6)1083 (11.9)0.60 (0.22 to 1.67)0.330.63 (0.23 to 1.76)0.38
 Anterior and posterior1086 (11.9)7 (13.2)1079 (11.9)1.13 (0.51 to 2.50)0.771.22 (0.54 to 2.72)0.64
ECAS1047 (11.5)11 (20.8)1036 (11.4)2.03 (1.04 to 3.96)0.042.29 (1.16 to 4.51)0.02
ECAS without ICAS367 (4.0)6 (11.3)361 (4.0)3.08 (1.31 to 7.25)0.013.39 (1.43 to 8.06)0.006
ICAS and ECAS680 (7.5)5 (9.4)675 (7.4)1.30 (0.51 to 3.27)0.581.43 (0.56 to 3.66)0.45

  • *Adjusted model: adjusted by age, sex, BMI, smoking status and medical history (hypertension, diabetes mellitus and dyslipidaemia).

  • BMI, body mass index; ECAS, extracranial arterial stenosis; ICAS, intracranial arterial stenosis.