Primary and secondary outcomes in patients treated with early versus routine anticoagulation
| Early anticoagulation (n=141) | Routine anticoagulation (n=116) | P value | OR (95% CI) | P value* | a(c)OR (95% CI)* | |
| Primary outcomes | ||||||
| mRS | 2 (1–4) | 3 (1–4) | 0.01 | 1.81 (1.15 to 2.83) | 0.01 | 2.08 (1.27 to 3.41) |
| sICH† | 2 (1.4%) | 3 (2.6%) | 0.83 | 0.54 (0.09 to 3.30) | 0.19 | 0.20 (0.02 to 2.18) |
| Secondary outcomes | ||||||
| mRS≤2 | 82 (58.2%) | 53 (45.7%) | 0.05 | 1.65 (1.01 to 2.71) | 0.01 | 2.28 (1.21 to 4.31) |
| Mortality | 7 (5.0%) | 20 (17.2%) | <0.01 | 0.25 (0.10 to 0.62) | 0.01 | 0.26 (0.09 to 0.71) |
| aICH | 24 (17.0%) | 14 (12.1%) | 0.27 | 1.50 (0.73 to 3.04) | 0.43 | 1.40 (0.61 to 3.18) |
| New ischaemic stroke | 9 (6.4%) | 7 (6.0%) | 0.91 | 1.06 (0.38 to 2.94) | 0.86 | 1.11 (0.36 to 3.40) |
Comparison of the outcomes of early and routine anticoagulation.
*Adjusted for age, history of hypertension, baseline NIHSS, baseline glucose level, baseline ASPECTS, treatment with intravenous thrombolysis, heparin during procedure, and onset to reperfusion time.
†Not adjusted for age, history of hypertension, baseline ASPECTS and onset to reperfusion time due to the low incidence of sICH.
a(c)OR, adjusted common OR; aICH, asymptomatic intracranial haemorrhage; ASPECTS, Alberta Stroke Programme Early CT Score; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage.