Baseline characteristics for study cohort by composite outcome and vascular events
| Total (n=722) | Composite events | Recurrent stroke | Acute coronary syndrome | Vascular death | ||
| Yes (n=109) | No (n=613) | Yes (n=74) | Yes (n=20) | Yes (n=15) | ||
| Age (years), mean (±SD) | 69 (±10) | 70 (±10) | 68 (±10) | 70 (±10) | 70 (±7) | 70 (±10) |
| Sex, n (%) | ||||||
| Female | 251 (34.8) | 36 (33.0) | 215 (35.1) | 25 (33.8) | 5 (25.0) | 6 (40.0) |
| Male | 471 (65.2) | 73 (67.0) | 398 (64.9) | 49 (66.2) | 15 (75.0) | 9 (60.0) |
| Study arm, n (%) | ||||||
| Conventional care | 352 (48.8) | 57 (52.3) | 295 (48.1) | 38 (51.4) | 12 (60.0) | 7 (46.7) |
| Intensified care | 370 (51.2) | 52 (47.7) | 318 (51.9) | 36 (48.6) | 8 (40.0) | 8 (53.3) |
| BMI (kg/m2), mean (±SD) | 28 (±4) | 28 (±4) | 28 (±4) | 28 (±4) | 28 (±5) | 29 (±4) |
| ABCD2, median (IQR) | 4 (4–5) | 5 (4–6) | 4 (4–5) | 5 (4–6) | 5 (4–5) | 4 (4–5) |
| NIHSS, median (IQR)* | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 2 (0–2) |
| Carotid surgery, n (%) | 22 (3.0) | 7 (6.4) | 15 (2.4) | 3 (4.1) | 3 (15.0) | 1 (6.7) |
| Vascular risk factors, n (%) | ||||||
| Hypertension | 640 (88.6) | 99 (90.8) | 541 (88.3) | 67 (90.5) | 19 (95.0) | 13 (86.7) |
| Diabetes mellitus | 174 (24.1) | 37 (33.9) | 137 (22.3) | 24 (32.4) | 7 (35.0) | 6 (40.0) |
| Atrial fibrillation | 127 (17.6) | 16 (14.7) | 111 (18.1) | 13 (17.6) | 2 (10.0) | 1 (6.7) |
| Smoking | 127 (17.6) | 23 (21.1) | 104 (17.0) | 12 (16.2) | 6 (30.0) | 5 (33.3) |
| Index event, n (%) | ||||||
| TIA | 326 (45.2) | 39 (35.8) | 287 (46.8) | 30 (40.5) | 5 (25.0) | 4 (26.7) |
| Minor stroke | 396 (54.8) | 70 (64.2) | 326 (53.2) | 44 (59.5) | 15 (75.0) | 11 (73.3) |
| Stroke aetiology, n (%) | ||||||
| Large vessel atherosclerosis | 67 (9.3) | 13 (11.9) | 54 (8.8) | 8 (10.8) | 4 (20.0) | 1 (6.7) |
| Cardioembolism | 133 (18.4) | 17 (15.6) | 116 (18.9) | 11 (14.9) | 4 (20.0) | 2 (13.3) |
| Small vessel disease | 59 (8.2) | 11 (10.1) | 48 (7.8) | 4 (5.4) | 6 (30.0) | 1 (6.7) |
| Other aetiology | 11 (1.5) | 3 (2.8) | 8 (1.3) | 3 (4.1) | 0 (0) | 0 (0) |
| Undetermined cause | 452 (62.6) | 65 (59.6) | 385 (63.1) | 48 (64.9) | 6 (30.0) | 11 (73.3) |
| Previous vascular event, n (%) | ||||||
| TIA† | 40 (5.7) | 11 (10.8) | 29 (4.9) | 9 (12.9) | 0 (0) | 2 (14.3) |
| Stroke‡ | 117 (16.5) | 26 (24.8) | 91 (15.0) | 16 (22.2) | 9 (47.4) | 1 (7.1) |
| Myocardial infarction§ | 57 (8.0) | 15 (14.0) | 42 (6.9) | 7 (9.6) | 5 (26.3) | 3 (20.0) |
| Fundus groups, n (%) | ||||||
| No or mild vascular retinopathy | 155 (21.5) | 27 (24.8) | 128 (20.9) | 16 (21.6) | 7 (35.0) | 4 (26.7) |
| Moderate vascular retinopathy | 473 (65.5) | 60 (55.0) | 413 (67.4) | 43 (58.1) | 7 (35.0) | 10 (66.7) |
| Vascular retinopathy with vessel rarefaction | 94 (13.0) | 22 (20.2) | 72 (11.7) | 15 (20.3) | 6 (30.0) | 1 (6.7) |
*Data available for 720 patients.
†Data available for 696 patients.
‡Data available for 710 patients.
§Data available for 714 patients.
ABCD2, age, blood pressure, clinical findings, duration of symptoms and presence or absence of diabetes; BMI, body mass index; NIHSS, National Institute of Health Stroke Scale; TIA, transient ischaemic attack.