Table 2

Cox regression model of the association between Framingham General Cardiovascular Risk Score (FGCRS) and dementia

Models	FGCRS	ACD		AD		VaD
Models	FGCRS	HR and 95% CI	P value	HR and 95% CI	P value	HR and 95% CI	P value
Unadjusted	Continuous	1.167 (1.159 to 1.175)	<0.001	1.173 (1.159 to 1.186)	<0.001	1.207 (1.187 to 1.226)	<0.001
	Low risk	Reference		Reference		Reference
	Intermediate risk	2.966 (2.655 to 3.313)	<0.001	3.220 (2.720 to 3.817)	<0.001	3.390 (2.611 to 4.400)	<0.001
	High risk	5.672 (5.103 to 6.305)	<0.001	5.810 (4.936 to 6.839)	<0.001	8.272 (6.459 to 10.600)	<0.001
Multiadjusted	Continuous	1.158 (1.150 to 1.167)	<0.001	1.163 (1.150 to 1.177)	<0.001	1.188 (1.169 to 1.208)	<0.001
	Low risk	Reference		Reference		Reference
	Intermediate risk	2.873 (2.569 to 3.214)	<0.001	3.186 (2.685 to 3.782)	<0.001	3.111 (2.39 to 4.043)	<0.001
	High risk	5.555 (4.990 to 6.183)	<0.001	5.841 (4.951 to 6.892)	<0.001	7.526 (5.866 to 9.655)	<0.001

Multiadjusted: adjusted for education, alcohol intake, BMI, MET-min/wk, ApoE ε4, Townsend Deprivation Index, pacemaker, cholesterol-lowering medication, and insulin use.
ACD, all-cause dementia; AD, Alzheimer’s disease; BMI, body mass index; CI, confidential interval; HR, Hazards ratio; MET, metabolic equivalent of task; VaD, vascular dementia.