Recurrent event analysis using the Prentice, Williams and Peterson Gap-Time model for risk factors associated with haemorrhage in 411 CCMs
| Factor | Univariate analysis | Multivariate analysis | ||
| P value | HR (95% CI) | P value | HR (95% CI) | |
| Gender female | 0.243 | 1.21 (0.88 to 1.67) | ||
| Familial form | 0.821 | 0.77 (0.06 to 9.43) | ||
| Developmental venous anomaly | 0.014 | 1.69 (1.11 to 2.57) | 0.022 | 1.60 (1.07 to 2.40) |
| Location brainstem vs others | 0.022 | 1.44 (1.05 to 1.96) | 0.072 | 1.31 (0.98 to 1.75) |
| Prior surgery | 0.559 | 1.18 (0.68 to 2.04) | ||
| Stereotactic radiosurgery | <0.0001 | 0.25 (0.15 to 0.41) | <0.0001 | 0.27 (0.17 to 0.44) |
CCM, cerebral cavernous malformation.