Cox analysis for factor associated with new haemorrhage after SRS in 413 CCMs*
| Factor | Univariate analysis | Multivariate analysis | ||
| P value | HR (95% CI) | P value | HR (95% CI) | |
| Gender female | 0.68 | 1.14 (0.61 to 2.13) | ||
| Developmental venous anomaly | 0.037 | 2.15 (1.05 to 4.40) | 0.049 | 2.08 (1.00 to 4.31) |
| Age at SRS >65 | 0.037 | 3.02 (1.07 to 8.52) | 0.052 | 2.81 (0.99 to 7.95) |
| Volume >0.7 cc | 0.042 | 1.94 (1.02 to 3.66) | 0.064 | 1.85 (0.96 to 3.53) |
| Margin >13 Gy | 0.003 | 2.63 (1.39 to 4.98) | 0.012 | 2.27 (1.20 to 4.32) |
| Location brainstem vs others | 0.65 | 1.16 (0.62 to 2.15) | ||
| Multiple haemorrhages pre-SRS | 0.048 | 1.90 (1.00 to 3.60) | 0.071 | 1.80 (0.95 to 3.42) |
*The analysis was performed on 413 CCM, as volumetric measurements on one CCM were missing
CCM, cerebral cavernous malformation; SRS, stereotactic radiosurgery.