Table 3

Annual haemorrhage rate per 100 CCM-years

	Annual haemorrhage rate per 100 CCM-years
	Pre-SRS	Post-SRS
	Pre-SRS	<2-year post-SRS	≥2-year post-SRS	Overall
Overall cohort
From birth	3.31	4.53	1.44	2.7
From diagnosis with first haemorrhage included	43.35
From diagnosis with first haemorrhage excluded*	11.08
Single haemorrhage before SRS (n=324)
From birth	2.66	3.6	1.48	2.38
From diagnosis with first haemorrhage included	47.86
From diagnosis with first haemorrhage excluded*	3.1
Multiple haemorrhages before SRS (n=90)
From birth	5.45	7.78	1.36	3.68
From diagnosis with first haemorrhage included	37.71
From diagnosis with first haemorrhage excluded*	21.07

*Except when the diagnosis was before the first haemorrhage (n=21 cases for overall series and single bleed patients).
CCM, cerebral cavernous malformations; SRS, stereotactic radiosurgery.