Adjudicated baseline imaging characteristics (old vascular and non-stroke lesions) by small vessel disease score as determined by recruiting site
| Variable | N | All | SVD | Score | P value |
| Low | Moderate- severe | ||||
| Patients randomised | 363 | 99 | 264 | ||
| Old vascular lesions (%) | 362 | 224 (61.9) | 38 (38.8) | 186 (70.5) | <0.0001 |
| Old cortical infarct | 224 | 11 (4.9) | 1 (2.6) | 10 (5.4) | 0.70 |
| Old striatocapsular infarct | 224 | 2 (0.9) | 1 (2.6) | 1 (0.5) | 0.31 |
| Old borderzone infarct | 224 | 2 (0.9) | 1 (2.6) | 1 (0.5) | 0.31 |
| Old lacunar infarct | 224 | 216 (96.4) | 36 (94.7) | 180 (96.8) | 0.54 |
| No of lacunes (%) | 224 | 0.11 | |||
| 1 | 40 (17.9) | 10 (26.3) | 30 (16.1) | ||
| 2 | 46 (20.5) | 8 (21.1) | 38 (20.4) | ||
| 3 | 42 (18.8) | 8 (21.1) | 34 (18.3) | ||
| 4 | 26 (11.6) | 6 (15.8) | 20 (10.8) | ||
| ≥5 | 62 (27.7) | 4 (10.5) | 58 (31.2) | ||
| Old brainstem/cerebellar non-lacunar infarcts | 224 | 35 (15.6) | 2 (5.3) | 33 (17.7) | 0.083 |
| Probable old haemorrhage | 224 | 4 (1.8) | 0 (0.0) | 4 (2.2) | 1.00 |
| Non-stroke lesions (%) | |||||
| Non-stroke lesion present | 362 | 13 (3.6) | 3 (3.1) | 10 (3.8) | 1.00 |
| Classification of non-stroke (%) | 13 | ||||
| Cerebral tumour | 2 (15.4) | 0 (0.0) | 2 (20.0) | 1.00 | |
| Aneurysm | 1 (7.7) | 0 (0.0) | 1 (10.0) | 1.00 | |
| Vascular malformation | 1 (7.7) | 1 (33.3) | 0 (0.0) | 1.00 | |
| Other non-stroke classification | 8 (61.5) | 2 (66.7) | 6 (60.0) | 1.00 |
Data are number (%), median (IQR), or mean (SD). The number of participants with data is 363 unless stated.