Area of under curve (AUC), cut-off value, sensitivity, specificity, Yonden Index for EMVs and EMV-miR-125a-5p in IS
| Items | AUC | Cut-off value | Sensitivity (%) | Specificity (%) | Youden Index |
| EMVs | 0.720 | ＞2.389×109/ mL | 85 | 63 | 0.389 |
| EMV-miR-125a-5p | 0.832 | ＜0.0002639 nmol/L | 76 | 82.5 | 0.4296 |
| EMVs+EMV-miR-125a-5p | 0.881 | ＞0.7017 | 76 | 89.7 | 0.5037 |
MiR-125a-5p enrichment promoted the effects of Control EMVs and n-EMVs on decreasing CBF reduction, infarct volume and NDS, while IS EMVs and OGD-EMVs had detrimental effects.
CBF, cerebral blood flow; EMVs, endothelial microvesicles; IS, ischaemic stroke; NDS, Neurological Deficit Score.