HRs estimation for myocardial infarction, all-cause mortality and haemorrhagic and ischaemic stroke among different HDL-C/LDL-C groups by subgroup analyses of age-disaggregated and gender-disaggregated analyses
| Subgroup | N | 0.4–0.6 | <0.4 | >0.6 | ||
| Re | HR (95% CI) | P value | HR (95% CI) | P value | ||
| Gender (model 1) | ||||||
| Female | ||||||
| All-cause mortality | 9752 | Re | 0.99 (0.94 to 1.04) | 0.586 | 1.15 (1.09 to 1.22) | <0.001 |
| MI | 1948 | Re | 1.41 (1.26 to 1.57) | <0.001 | 1.12 (0.96 to 1.30) | 0.144 |
| Ischaemic stroke | 1178 | Re | 0.98 (0.86 to 1.13) | 0.822 | 1.02 (0.85 to 1.22) | 0.822 |
| Haemorrhagic stroke | 537 | Re | 1.11 (0.90 to 1.36) | 0.324 | 1.25 (0.97 to 1.59) | 0.079 |
| Male | ||||||
| All-cause mortality | 13 310 | Re | 0.96 (0.92 to 1.00) | <0.05 | 1.29 (1.21 to 1.37) | <0.001 |
| MI | 4784 | Re | 1.31 (1.22 to 1.40) | <0.001 | 0.89 (0.77 to 1.01) | 0.077 |
| Ischaemic stroke | 1786 | Re | 1.2 (1.07 to 1.34) | <0.01 | 1.11 (0.96 to 1.21) | 0.075 |
| Haemorrhagic stroke | 489 | Re | 0.87 (0.71 to 1.08) | 0.219 | 1.32 (0.96 to 1.81) | <0.05 |
| Age (model 2) | ||||||
| <60 (years) | ||||||
| All-cause mortality | 6876 | Re | 0.94 (0.89 to 1.00) | <0.05 | 1.23 (1.13 to 1.33) | <0.001 |
| MI | 2444 | Re | 1.66 (1.49 to 1.85) | <0.001 | 0.96 (0.79 to 1.16) | 0.657 |
| Ischaemic stroke | 867 | Re | 1.14 (0.96 to 1.34) | 0.127 | 1.12 (0.87 to 1.45) | 0.362 |
| Haemorrhagic stroke | 390 | Re | 1.04 (0.81 to 1.33) | 0.774 | 1.42 (1.03 to 1.94) | <0.05 |
| ≥60 (years) | ||||||
| All-cause mortality | 16 186 | Re | 0.98 (0.95 to 1.02) | 0.382 | 1.19 (1.14 to 1.26) | <0.001 |
| MI | 4288 | Re | 1.24 (1.16 to 1.33) | <0.001 | 0.97 (0.86 to 1.08) | 0.555 |
| Ischaemic stroke | 2097 | Re | 1.11 (1.00 to 1.22) | <0.05 | 1.09 (0.94 to 1.26) | 0.256 |
| Haemorrhagic stroke | 636 | Re | 0.97 (0.81 to 1.17) | 0.782 | 1.15 (0.9 to 1.48) | 0.264 |
HRs were estimated by Cox proportional risk model. Model 1 was adjusted for age, TDI, race, smoking history, education level, alcohol use, BMI, BG, SBP, DBP and TG; model 2 was the same as model 1 with the addition of adjustment for gender.
BG, blood glucose; BMI, body mass index; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MI, myocardial infarction; Re, reference; SBP, systolic blood pressure; TDI, Townsend Deprivation Index; TG, triglycerides.