Baseline characteristics and outcomes of the study
| Characteristics | Total cohort (n=2844) | Training cohort (n=2111) | Validation cohort (n=733) | P value |
| Demographic characteristics | ||||
| Age (years) | 62 (53–70) | 62 (53–71) | 60 (51–68) | <0.001 |
| Male | 1920 (67.5) | 1421 (67.3) | 499 (68.1) | 0.704 |
| Medical history | ||||
| Ischaemic stroke | 288 (10.1) | 183 (8.7) | 105 (14.3) | <0.001 |
| Ischaemic heart disease | 99 (3.5) | 76 (3.6) | 23 (3.1) | 0.556 |
| Hypertension | 1838 (64.6) | 1362 (64.5) | 476 (64.9) | 0.838 |
| Hyperlipidaemia | 69 (2.4) | 47 (2.2) | 22 (3.0) | 0.240 |
| Diabetes | 261 (9.2) | 188 (8.9) | 73 (10.0) | 0.395 |
| Admission characteristics | ||||
| Prestroke mRS | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.008 |
| SBP (mm Hg) | 167 (150–187) | 167 (150–187) | 167 (151–187) | 0.334 |
| Baseline NIHSS | 8 (4–15) | 7 (3–14) | 11 (5–17) | <0.001 |
| Deep location | 2336 (82.1) | 1723 (81.6) | 613 (83.6) | 0.221 |
| Volume of haematoma (mL) | 12.0 (5.0–26.0) | 12.0 (5.0–25.0) | 12.0 (5.1–30.0) | 0.141 |
| IVH | 321 (11.3) | 237 (11.2) | 84 (11.5) | 0.864 |
| Admission laboratory values | ||||
| White cell count (×109/L) | 8.4 (6.4–10.9) | 8.2 (6.3–10.7) | 8.8 (6.9–11.8) | <0.001 |
| Hb (g/L) | 136 (124–147) | 135 (123–146) | 139 (126–151) | <0.001 |
| PLT (×109/L) | 195 (155–238) | 188 (149–231) | 215 (175–260) | <0.001 |
| ANC (×109/L) | 6.3 (4.5–9.1) | 6.2 (4.5–8.9) | 6.5 (4.6–9.6) | 0.019 |
| ALC (×109/L) | 1.2 (0.8–1.6) | 1.1 (0.8–1.6) | 1.3 (0.9–1.9) | <0.001 |
| ALT (U/L) | 18 (13–26) | 18 (13–26) | 19 (14–27) | 0.005 |
| AST (U/L) | 23 (18–30) | 23 (18–30) | 23 (18–30) | 0.933 |
| GFR (mL/min/1.73 m2) | 94 (80–104) | 93 (80–103) | 95 (81–106) | 0.006 |
| UA (μmol/L) | 308 (243–383) | 311 (244–388) | 307(238-369) | 0.003 |
| FBG (mmol/L) | 6.2 (5.3–7.7) | 6.1 (5.2–7.7) | 6.5 (5.5–7.9) | 0.001 |
| INR | 1.0 (0.9–1.1) | 1.0 (1.0–1.1) | 0.9 (0.9–1.0) | <0.001 |
| Outcome | ||||
| Death at 90 days | 469 (16.5) | 337 (16.0) | 132 (18.0) | 0.199 |
| mRS at 90 days | ||||
| 0–2 | 1405 (49.4) | 1074 (50.9) | 331 (45.2) | 0.008 |
| 3–6 | 1439 (50.6) | 1037 (49.1) | 402 (54.8) | |
Continuous and ordinal variables were reported as median (IQR), and categorical variables were presented as n (%).
P<0.05 was represented in bold type.
ALC, absolute lymphocyte count; ALT, glutamic pyruvic transaminase; ANC, absolute neutrophil count; AST, aspartate aminotransferase; FBG, fasting blood glucose; GFR, glomerular filtration rate; Hb, haemoglobin; INR, international normalised ratio; IVH, intraventricular haemorrhage; mRS, modified Rankin Scale NIHSS, National Institutes of Health Stroke Scale; PLT, platelet; SBP, systolic blood pressure; UA, uric acid.